ArticleeLife2017
Computational models of O-LM cells are recruited by low or high theta frequency inputs depending on h-channel distributions.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 32 citations in OpenAlex.
- Differentiated Presynaptic Input to OLMɑ2 Cells Along the Hippocampal Dorsoventral Axis: Implications for Hippocampal Microcircuit Function.Hippocampus · 2025Article
- Synaptic and dendritic architecture of different types of hippocampal somatostatin interneurons.PLoS biology · 2024Article
- Theta-gamma phase amplitude coupling in a hippocampal CA1 microcircuit.PLoS computational biology · 2023Article
- Reduced oriens-lacunosum/moleculare cell model identifies biophysical current balances forFrontiers in neural circuits · 2023Article
- The role of inhibitory circuits in hippocampal memory processing.Nature reviews. Neuroscience · 2022Review
- Septohippocampal transmission from parvalbumin-positive neurons features rapid recovery from synaptic depression.Scientific reports · 2021Article
- Modeling Reveals Human-Rodent Differences in H-Current Kinetics Influencing Resonance in Cortical Layer 5 Neurons.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Effects of Several Classes of Voltage-Gated Ion Channel Conductances on Gamma and Theta Oscillations in a Hippocampal Microcircuit Model.Frontiers in computational neuroscience · 2021Article
- Presynaptic GABAeLife · 2020Article
- Integration of Within-Cell Experimental Data With Multi-Compartmental Modeling Predicts H-Channel Densities and Distributions in Hippocampal OLM Cells.Frontiers in cellular neuroscience · 2020Article
- Computationally going where experiments cannot: a dynamical assessment of dendritic ion channel currents duringF1000Research · 2020Article
- Input-Specific Synaptic Location and Function of the α5 GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Article
- Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor.Nature communications · 2018Article
- Combining Theory, Model, and Experiment to Explain How Intrinsic Theta Rhythms Are Generated in aneNeuroArticle
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Although biophysical details of inhibitory neurons are becoming known, it is challenging to map these details onto function. Oriens-lacunosum/moleculare (O-LM) cells are inhibitory cells in the hippocampus that gate information flow, firing while phase-locked to theta rhythms. We build on our existing computational model database of O-LM cells to link model with function. We place our models in high-conductance states and modulate inhibitory inputs at a wide range of frequencies. We find preferred spiking recruitment of models at high (4-9 Hz) or low (2-5 Hz) theta depending on, respectively, the presence or absence of h-channels on their dendrites. This also depends on slow delayed-rectifier potassium channels, and preferred theta ranges shift when h-channels are potentiated by cyclic AMP. Our results suggest that O-LM cells can be differentially recruited by frequency-modulated inputs depending on specific channel types and distributions. This work exposes a strategy for understanding how biophysical characteristics contribute to function.
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