Evidence map›Paper›PMID 28318486›Full record

ArticleeLife2017

Structural basis of transcription arrest by coliphage HK022 Nun in an

Jin Young Kang, Paul Dominic B Olinares, James Chen, Elizabeth A Campbell, Arkady Mustaev, Brian T Chait, Max E Gottesman, Seth A Darst

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
17.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 135 citations in OpenAlex.

  1. Article
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  4. Bioluminescent Probes for Multiplexed RNA Imaging.Journal of the American Chemical Society · 2026
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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jin Young KangLaboratory of Molecular Biophysics, The Rockefeller University, New York City, United States.
Paul Dominic B OlinaresLaboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York City, United States.
James ChenLaboratory of Molecular Biophysics, The Rockefeller University, New York City, United States.
Elizabeth A CampbellLaboratory of Molecular Biophysics, The Rockefeller University, New York City, United States.
Arkady MustaevPublic Health Research Institute, Newark, United States.
Brian T ChaitLaboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York City, United States.
Max E GottesmanDepartment of Microbiology and Immunology, Columbia University Medical Center, New York City, United States.
Seth A DarstLaboratory of Molecular Biophysics, The Rockefeller University, New York City, United States.ORCID 0000-0002-8241-3153
Rockefeller University · USColumbia University Irving Medical Center · USRutgers, The State University of New Jersey · US

Funding

TR&D Project 4. The Imaging Stage: Multiscale Spatiotemporal Modeling of Macromolecular Systems in Cellular NeighborhoodsP41GM109824 · NIGMS · ROCKEFELLER UNIVERSITY · PI ROUT, MICHAEL P · 2014 to 2023
$18.8M
National Resource for Mass Spectrom of Biological MacromoleculesP41GM103314 · NIGMS · ROCKEFELLER UNIVERSITY · PI CHAIT, BRIAN T · 2012 to 2017
$9.9M
Structure, function, and regulation of the bacterial transcription cycleR35GM118130 · NIGMS · ROCKEFELLER UNIVERSITY · PI DARST, SETH A. · 2016 to 2025
$8.9M
CONTROL OF TRANSCRIPTION TERMINATION IN E. COLIR01GM037219 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GOTTESMAN, MAX ELLIOT · 1986 to 2017
$6.6M
NIGMS NIH HHS P41 GM103314NIGMS NIH HHS P41 GM109824NIGMS NIH HHS R01 GM037219NIGMS NIH HHS R35 GM118130
6 · The paper itself

Abstract

Coliphage HK022 Nun blocks superinfection by coliphage λ by stalling RNA polymerase (RNAP) translocation specifically on λ DNA. To provide a structural framework to understand how Nun blocks RNAP translocation, we determined structures of

Indexed as

Transcription, GeneticCryoelectron MicroscopyDNA-Directed RNA PolymerasesEscherichia coliProtein BindingProtein ConformationTranscription FactorsViral ProteinsDNA-Directed RNA PolymerasesNun protein, Enterobacteria phage HK022Transcription FactorsViral ProteinsbiochemistrybiophysicsCryo-electron microscopyE. coliHK022NunRNA polymerasestructural biologyTranscription

Identifiers

PMID28318486
PMCPMC5386594
OpenAlexW2599962490

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.