Evidence map›Paper›PMID 28318403›Full record

ArticleRadiology2017

Familial Cerebral Cavernous Malformations Are Associated with Adrenal Calcifications on CT Scans: An Imaging Biomarker for a Hereditary Cerebrovascular Condition.

Corinne D Strickland, Steven C Eberhardt, Mary R Bartlett, Jeffrey Nelson, Helen Kim, Leslie A Morrison, Blaine L Hart

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01764529 (Modifiers of Disease Severity and Progression in Cerebral Cavernous Malformations), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01764529 completednot on this map

Modifiers of Disease Severity and Progression in Cerebral Cavernous Malformations

Typeobservational_patient_registrySponsorUniversity of California, San FranciscoRan2010 to 2025Enrolled789ConditionsCavernous Angioma, Familial, Cerebral Cavernous Malformations, Cerebral Cavernous Hemangioma
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Corinne D StricklandFrom the Departments of Radiology (C.D.S., S.C.E., B.L.H.) and Neurology (M.R.B., L.A.M.), University of New Mexico Health Sciences Center, MSC 10 5530, 1 University of New Mexico, Albuquerque, NM 87131; and Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, Calif (J.N., H.K.).
Steven C EberhardtFrom the Departments of Radiology (C.D.S., S.C.E., B.L.H.) and Neurology (M.R.B., L.A.M.), University of New Mexico Health Sciences Center, MSC 10 5530, 1 University of New Mexico, Albuquerque, NM 87131; and Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, Calif (J.N., H.K.).
Mary R BartlettFrom the Departments of Radiology (C.D.S., S.C.E., B.L.H.) and Neurology (M.R.B., L.A.M.), University of New Mexico Health Sciences Center, MSC 10 5530, 1 University of New Mexico, Albuquerque, NM 87131; and Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, Calif (J.N., H.K.).
Jeffrey NelsonFrom the Departments of Radiology (C.D.S., S.C.E., B.L.H.) and Neurology (M.R.B., L.A.M.), University of New Mexico Health Sciences Center, MSC 10 5530, 1 University of New Mexico, Albuquerque, NM 87131; and Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, Calif (J.N., H.K.).
Helen KimFrom the Departments of Radiology (C.D.S., S.C.E., B.L.H.) and Neurology (M.R.B., L.A.M.), University of New Mexico Health Sciences Center, MSC 10 5530, 1 University of New Mexico, Albuquerque, NM 87131; and Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, Calif (J.N., H.K.).
Leslie A MorrisonFrom the Departments of Radiology (C.D.S., S.C.E., B.L.H.) and Neurology (M.R.B., L.A.M.), University of New Mexico Health Sciences Center, MSC 10 5530, 1 University of New Mexico, Albuquerque, NM 87131; and Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, Calif (J.N., H.K.).
Blaine L HartFrom the Departments of Radiology (C.D.S., S.C.E., B.L.H.) and Neurology (M.R.B., L.A.M.), University of New Mexico Health Sciences Center, MSC 10 5530, 1 University of New Mexico, Albuquerque, NM 87131; and Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, Calif (J.N., H.K.).
University of New Mexico · US

Funding

UNM HSC Clinical and Translational Science CenterUL1TR001449 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CAMPEN, MATTHEW J, PANDHI, NANCY · 2015 to 2024
$36.9M
VCRC Administration UnitU54NS065705 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KIM, HELEN · 2009 to 2023
$20.8M
NCATS NIH HHS UL1 TR001449NINDS NIH HHS U54 NS065705
6 · The paper itself

Abstract

Purpose To determine if adrenal calcifications seen at computed tomography (CT) are associated with familial cerebral cavernous malformations (fCCMs) in carriers of the CCM1 Common Hispanic Mutation. Materials and Methods This study was approved by the institutional review board. The authors retrospectively reviewed abdominal CT scans in 38 patients with fCCM, 38 unaffected age- and sex-matched control subjects, and 13 patients with sporadic, nonfamilial cerebral cavernous malformation (CCM). The size, number, and laterality of calcifications and the morphologic characteristics of the adrenal gland were recorded. Brain lesion count was recorded from brain magnetic resonance (MR) imaging in patients with fCCM. The prevalence of adrenal calcifications in patients with fCCM was compared with that in unaffected control subjects and those with sporadic CCM by using the Fisher exact test. Additional analyses were performed to determine whether age and brain lesion count were associated with adrenal findings in patients with fCCM. Results Small focal calcifications (SFCs) (≤5 mm) were seen in one or both adrenal glands in 19 of the 38 patients with fCCM (50%), compared with 0 of the 38 unaffected control subjects (P < .001) and 0 of the 13 subjects with sporadic CCM (P = .001). Adrenal calcifications in patients with fCCM were more frequently left sided, with 17 of 19 patients having more SFCs in the left adrenal gland than the right adrenal gland and 50 of the 61 observed SFCs (82%) found in the left adrenal gland. No subjects had SFCs on the right side only. In patients with fCCM, the presence of SFCs showed a positive correlation with age (P < .001) and number of brain lesions (P < .001). Conclusion Adrenal calcifications identified on CT scans are common in patients with fCCM and may be a clinically silent manifestation of disease.

Indexed as

AdolescentAdrenal Gland DiseasesAdultBiomarkersCalcinosisCase-Control StudiesChildContrast MediaDiagnosis, DifferentialFemaleHemangioma, Cavernous, Central Nervous SystemHumansKRIT1 ProteinMagnetic Resonance ImagingMaleMicrotubule-Associated ProteinsBiomarkersContrast MediaKRIT1 ProteinKRIT1 protein, humanMicrotubule-Associated ProteinsProto-Oncogene Proteins

Identifiers

PMID28318403
PMCPMC5519414
OpenAlexW2601471317

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.