Evidence map›Paper›PMID 28317921›Full record

ArticleScientific reports2017

Self-renewal and phenotypic conversion are the main physiological responses of macrophages to the endogenous estrogen surge.

Giovanna Pepe, Daniele Braga, Tiziana A Renzi, Alessandro Villa, Chiara Bolego, Francesca D'Avila, Cristina Barlassina, Adriana Maggi, Massimo Locati, Elisabetta Vegeto

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 76 citations in OpenAlex.

  1. Article
  2. Sex Differences in the Lacrimal Gland: Implications for Dry Eye Disease.International journal of molecular sciences · 2025
    Review
  3. Biochanin A exerts an anti-inflammatory effect on adipose tissue and liver of ovariectomized obese mice.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025
    Article
  4. Review
  5. Article
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  11. Peritoneal resident macrophages in tumor metastasis and immunotherapy.Frontiers in cell and developmental biology · 2022
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Endometriosis and Cancer: Exploring the Role of Macrophages.International journal of molecular sciences · 2021
    Review
  20. Estrogen Receptor Functions and Pathways at the Vascular Immune Interface.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Giovanna PepeCenter of Excellence on Neurodegenerative Diseases and Department of Pharmacological and Biomolecular Sciences, University of Milan, Italy.
Daniele BragaDepartment of Health Sciences, University of Milan, Italy.
Tiziana A RenziDepartment of Medical Biotechnologies and Translational Medicine, University of Milan, Italy.
Alessandro VillaCenter of Excellence on Neurodegenerative Diseases and Department of Pharmacological and Biomolecular Sciences, University of Milan, Italy.
Chiara BolegoDepartment of Pharmaceutical Sciences, University of Padua, Italy.
Francesca D'AvilaDepartment of Health Sciences, University of Milan, Italy.
Cristina BarlassinaDepartment of Health Sciences, University of Milan, Italy.
Adriana MaggiCenter of Excellence on Neurodegenerative Diseases and Department of Pharmacological and Biomolecular Sciences, University of Milan, Italy.
Massimo LocatiDepartment of Medical Biotechnologies and Translational Medicine, University of Milan, Italy.
Elisabetta VegetoCenter of Excellence on Neurodegenerative Diseases and Department of Pharmacological and Biomolecular Sciences, University of Milan, Italy.
University of Milan · ITFondazione Filarete · ITHumanitas University · ITUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Beyond the physiology of reproduction, estrogen controls the homeostasis of several tissues. Although macrophages play a key role in tissue remodeling, the interplay with estrogen is still ill defined. Using a transcriptomic approach we first obtained a comprehensive list of genes that are differentially expressed in peritoneal macrophages in response to physiological levels of 17β-estradiol (E

Indexed as

TranscriptomeAngiopoietin-Like Protein 4AnimalsArginaseCell Cycle ProteinsCell ProliferationEstradiolFemaleGene Expression ProfilingGene Expression RegulationImmunity, InnateInterleukin-10Macrophage ActivationMacrophages, PeritonealMiceMice, Inbred C57BLAngiopoietin-Like Protein 4Angptl4 protein, mouseArg1 protein, mouseArginaseCell Cycle ProteinsEstradiolIL10 protein, mouseInterleukin-10Vascular Endothelial Growth Factor Avascular endothelial growth factor A, mouseZymosan

Identifiers

PMID28317921
PMCPMC5357836
OpenAlexW2599883686

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.