ArticleScientific reports2017
Novel hypophysiotropic AgRP2 neurons and pineal cells revealed by BAC transgenesis in zebrafish.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Emergence of appetite and circadian rhythmicity in Atlantic salmon brain transcriptome from endogenous to exogenous feeding.PloS one · 2026Article
- Article
- Optogenetic activation of hypothalamic AgRP neurons in transgenic zebrafish larvae increased food intake.Scientific reports · 2025Article
- Novel Transgenic Zebrafish Lines to Study the CHRNA3-B4-A5 Gene Cluster.Developmental neurobiology · 2025Article
- Motilin, a Novel Orexigenic Factor, Involved in Feeding Regulation in Yangtze Sturgeon (Biomolecules · 2024Article
- Article
- AgRP Neuron-Specific Ablation Represses Appetite, Energy Intake, and Somatic Growth in Larval Zebrafish.Biomedicines · 2023Article
- Mapping key neuropeptides involved in the melanocortin system in Atlantic salmon (Salmo salar) brain.The Journal of comparative neurology · 2023Article
- Genetic ablation of the Bsx homeodomain transcription factor in zebrafish: Impact on mature pineal gland morphology and circadian behavior.Journal of pineal research · 2022Article
- Distribution of two isoforms of tryptophan hydroxylase in the brain of rainbow trout (Oncorhynchus mykiss). An in situ hybridization study.Brain structure & function · 2021Article
- Functional Pituitary Networks in Vertebrates.Frontiers in endocrinology · 2020Review
- The Melanocortin System in Atlantic Salmon (Frontiers in neuroanatomy · 2020Article
- Conserved Genoarchitecture of the Basal Hypothalamus in Zebrafish Embryos.Frontiers in neuroanatomy · 2020Article
- Developmental and Cellular Basis of Vertical Bar Color Patterns in the East African Cichlid FishFrontiers in cell and developmental biology · 2020Article
- HypothalamicFrontiers in physiology · 2020Article
- Interference with the Cannabinoid Receptor CB1R Results in Miswiring of GnRH3 and AgRP1 Axons in Zebrafish Embryos.International journal of molecular sciences · 2019Article
- Evolutionary Dynamics of Structural Variation at a Key Locus for Color Pattern Diversification in Cichlid Fishes.Genome biology and evolution · 2019Article
- Agouti-Related Protein 2 Is a New Player in the Teleost Stress Response System.Current biology : CB · 2019Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
The neuropeptide agouti-related protein (AgRP) is expressed in the arcuate nucleus of the mammalian hypothalamus and plays a key role in regulating food consumption and energy homeostasis. Fish express two agrp genes in the brain: agrp1, considered functionally homologous with the mammalian AgRP, and agrp2. The role of agrp2 and its relationship to agrp1 are not fully understood. Utilizing BAC transgenesis, we generated transgenic zebrafish in which agrp1- and agrp2-expressing cells can be visualized and manipulated. By characterizing these transgenic lines, we showed that agrp1-expressing neurons are located in the ventral periventricular hypothalamus (the equivalent of the mammalian arcuate nucleus), projecting throughout the hypothalamus and towards the preoptic area. The agrp2 gene was expressed in the pineal gland in a previously uncharacterized subgroup of cells. Additionally, agrp2 was expressed in a small group of neurons in the preoptic area that project directly towards the pituitary and form an interface with the pituitary vasculature, suggesting that preoptic AgRP2 neurons are hypophysiotropic. We showed that direct synaptic connection can exist between AgRP1 and AgRP2 neurons in the hypothalamus, suggesting communication and coordination between AgRP1 and AgRP2 neurons and, therefore, probably also between the processes they regulate.
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