Evidence map›Paper›PMID 28317854›Full record

ArticleScientific reports2017

Sets of serum exosomal microRNAs as candidate diagnostic biomarkers for Kawasaki disease.

Hong-Ling Jia, Chao-Wu Liu, Li Zhang, Wei-Jun Xu, Xue-Juan Gao, Jun Bai, Yu-Fen Xu, Ming-Guo Xu, Gong Zhang

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
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  12. Epigenetics in Kawasaki Disease.Frontiers in pediatrics · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Hong-Ling JiaKey Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, Guangdong, China.
Chao-Wu LiuState Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, Guangzhou 510070, Guangdong, China.
Li ZhangGuangzhou Women and Children's Medical Center, Guangzhou 510120, Guangdong, China.
Wei-Jun XuInformation Center, Shenzhen Children's Hospital, Shenzhen, 518038, Guangdong, China.
Xue-Juan GaoKey Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, Guangdong, China.
Jun BaiFoshan Women and Children's Hospital, Foshan, 528000, Guangdong, China.
Yu-Fen XuGuangzhou Women and Children's Medical Center, Guangzhou 510120, Guangdong, China.
Ming-Guo XuDepartment of Pediatric Cardiology, Shenzhen Children's Hospital, Shenzhen, 518038, Guangdong, China.
Gong ZhangKey Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, Guangdong, China.
Jinan University · CNGuangzhou Women and Children Medical Center · CNShenzhen Children's Hospital · CNFoshan Maternity and Child Health Care Hospital · CNInstitute of Microbiology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although Kawasaki disease is the main cause of acquired heart disease in children, no diagnostic biomarkers are available. We aimed to identify candidate biomarkers for diagnosing Kawasaki disease using serum exosomal microRNAs (miRNAs). Using frozen serum samples from a biobank, high-throughput microarray technologies, two-stage real-time quantitative PCR, and a self-referencing strategy for data normalization, we narrowed down the list of biomarker candidates to a set of 4 miRNAs. We further validated the diagnostic capabilities of the identified miRNAs (namely, C

Indexed as

BiomarkersExosomesGene Expression ProfilingHumansMicroRNAsMucocutaneous Lymph Node SyndromeReference StandardsReproducibility of ResultsBiomarkersMicroRNAs

Identifiers

PMID28317854
PMCPMC5357789
OpenAlexW2598849731

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.