Evidence map›Paper›PMID 28317837›Full record

ArticleScientific reports2017

Inhibitory responses mediated by vagal nerve stimulation are diminished in stomachs of mice with reduced intramuscular interstitial cells of Cajal.

Elizabeth A H Beckett, Kenton M Sanders, Sean M Ward

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Differential responses to prostaglandins in the circular and longitudinal muscle layers of the murine ileum.American journal of physiology. Gastrointestinal and liver physiology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Excitatory cholinergic responses in mouse colon intramuscular interstitial cells of Cajal are due to enhanced CaFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  8. Review
  9. CaThe Journal of physiology · 2019
    Article
  10. Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Elizabeth A H BeckettDiscipline of Physiology, Adelaide Medical School, University of Adelaide, Adelaide, SA, 5005, Australia.
Kenton M SandersDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, 89557, USA.
Sean M WardDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, 89557, USA.
University of Nevada, Reno · USUniversity of Adelaide · AU

Funding

Tissue, Cell and Tissue Culture CoreP01DK041315 · NIDDK · UNIVERSITY OF NEVADA RENO · PI KEEF, KATHLEEN D · 1989 to 2018
$26.3M
Mechanisms underlying regional differences in gastric compliance in the stomach.R01DK057236 · NIDDK · UNIVERSITY OF NEVADA RENO · PI KENTON M SANDERS, Sean M Ward · 2000 to 2026
$7.1M
NIDDK NIH HHS P01 DK041315NIDDK NIH HHS R01 DK057236
6 · The paper itself

Abstract

Intramuscular interstitial cells of Cajal (ICC-IM) are closely associated with enteric motor nerve terminals and electrically coupled to smooth muscle cells within the gastric musculature. Previous studies investigating the role of ICC-IM in motor neurotransmission have used indiscriminate electric field stimulation of neural elements within the gastric wall. To determine the role of ICC-IM in transduction of vagally-mediated motor input to gastric muscles electrical and mechanical responses to selective electrical vagal stimulation (EVS) were recorded from gastric fundus and antral regions of wild type and W/W

Indexed as

Vagus Nerve StimulationAnimalsElectric StimulationHexamethoniumInterstitial Cells of CajalMice, Inbred C57BLMuscle RelaxationMuscle, SmoothNeuromuscular JunctionNicotinic AntagonistsNitric Oxide SynthaseReceptors, NicotinicStomachHexamethoniumNicotinic AntagonistsNitric Oxide SynthaseReceptors, Nicotinic

Identifiers

PMID28317837
PMCPMC5357897
OpenAlexW2598789448

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.