Evidence map›Paper›PMID 28317836›Full record

ArticleScientific reports2017

Microscale Symmetrical Electroporator Array as a Versatile Molecular Delivery System.

Mengxing Ouyang, Winfield Hill, Jung Hyun Lee, Soojung Claire Hur

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.3field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

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  10. Microfluidic and Nanofluidic Intracellular Delivery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Mengxing OuyangRowland Institute at Harvard University, 100 Edwin H. Land Blvd., Cambridge, MA 02142, USA.
Winfield HillRowland Institute at Harvard University, 100 Edwin H. Land Blvd., Cambridge, MA 02142, USA.
Jung Hyun LeeMassachusetts General Hospital, Charlestown, MA 02129, USA.
Soojung Claire HurRowland Institute at Harvard University, 100 Edwin H. Land Blvd., Cambridge, MA 02142, USA.
Harvard University · USMassachusetts General Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Successful developments of new therapeutic strategies often rely on the ability to deliver exogenous molecules into cytosol. We have developed a versatile on-chip vortex-assisted electroporation system, engineered to conduct sequential intracellular delivery of multiple molecules into various cell types at low voltage in a dosage-controlled manner. Micro-patterned planar electrodes permit substantial reduction in operational voltages and seamless integration with an existing microfluidic technology. Equipped with real-time process visualization functionality, the system enables on-chip optimization of electroporation parameters for cells with varying properties. Moreover, the system's dosage control and multi-molecular delivery capabilities facilitate intracellular delivery of various molecules as a single agent or in combination and its utility in biological research has been demonstrated by conducting RNA interference assays. We envision the system to be a powerful tool, aiding a wide range of applications, requiring single-cell level co-administrations of multiple molecules with controlled dosages.

Indexed as

CarbocyaninesCell Line, TumorElectroporationEquipment DesignGene Transfer TechniquesGreen Fluorescent ProteinsHEK293 CellsHumansMicroRNAsMicrotechnologyOvalbuminRNA, Small InterferingAlexa Fluor 647CarbocyaninesGreen Fluorescent ProteinsMicroRNAsOvalbuminRNA, Small Interfering

Identifiers

PMID28317836
PMCPMC5357946
OpenAlexW2603595115

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.