Evidence map›Paper›PMID 28317833›Full record

ArticleScientific reports2017

Regulation of NF-κB by PML and PML-RARα.

Abrar Ahmed, Xiaochun Wan, Izaskun Mitxitorena, Andrew J Lindsay, Pier Paolo Pandolfi, Mary W McCaffrey, Karen Keeshan, Youhai H Chen, Ruaidhrí J Carmody

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Genetic Determinants of Paget's Disease of Bone.Current osteoporosis reports · 2021
    Review
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Abrar AhmedDepartment of Biochemistry, University College Cork, Cork, Ireland.
Xiaochun WanShenzhen Institutes of Advanced Technology, Shenzhen, China.
Izaskun MitxitorenaGLAZgo Discovery Centre, Institute of Infection, Immunity &Inflammation, College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Andrew J LindsayDepartment of Biochemistry, University College Cork, Cork, Ireland.
Pier Paolo PandolfiDepartment of Pathology, Beth Israel Deaconess Medical Centre, Harvard University, Boston, MA, 02215, USA.
Mary W McCaffreyDepartment of Biochemistry, University College Cork, Cork, Ireland.
Karen KeeshanPaul O'Gorman Leukaemia Research Centre, College of Medicine, Veterinary and Life Sciences, Institute of Cancer Sciences, University of Glasgow, United Kingdom.
Youhai H ChenDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Ruaidhrí J CarmodyCentre for Immunobiology, Institute of Infection, Immunity &Inflammation, College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
University College Cork · IEUniversity of Glasgow · GBBeth Israel Deaconess Medical Center · USShenzhen Institutes of Advanced Technology · CNUniversity of Pennsylvania · US

Funding

Biotechnology and Biological Sciences Research Council BB/M003671/1Medical Research Council MR/M010694/1
6 · The paper itself

Abstract

Promyelocytic Leukemia (PML) is a nuclear protein that forms sub-nuclear structures termed nuclear bodies associated with transcriptionally active genomic regions. PML is a tumour suppressor and regulator of cell differentiation. We demonstrate that PML promotes TNFα-induced transcriptional responses by promoting NF-κB activity. TNFα-treated PML

Indexed as

Gene Expression RegulationAnimalsEmbryo, MammalianFibroblastsGene OntologyGenes, ReporterHEK293 CellsHumansLuciferasesMiceMolecular Sequence AnnotationNeoplasm ProteinsNF-KappaB Inhibitor alphaOncogene Proteins, FusionPlasmidsPromyelocytic Leukemia ProteinLuciferasesNeoplasm ProteinsNF-KappaB Inhibitor alphaOncogene Proteins, FusionPML protein, humanPromyelocytic Leukemia Proteinpromyelocytic leukemia-retinoic acid receptor alpha fusion oncoproteinTranscription Factor RelATumor Necrosis Factor-alpha

Identifiers

PMID28317833
PMCPMC5357907
OpenAlexW2589515779

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.