ArticleCartilage2017
PRP for Degenerative Cartilage Disease: A Systematic Review of Clinical Studies.
Article in Cartilage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 56 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Ultrasound Guided Platelet Rich Plasma Injections for Post Traumatic Greater Occipital Neuralgia: A Randomized Controlled Pilot Study
Low-Cost Platelet-Rich Plasma Injection for the Management of Hemarthropathy
Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 143 citations in OpenAlex.
- Pooled it
- Intra-articular platelet-rich plasma injections versus intra-articular corticosteroid injections for symptomatic management of knee osteoarthritis: systematic review and meta-analysis.BMC musculoskeletal disorders · 2021Pooled it
- Intra-articular injection of culture-expanded mesenchymal stem cells with or without addition of platelet-rich plasma is effective in decreasing pain and symptoms in knee osteoarthritis: a controlled, double-blind clinical trial.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2020Trial
- Perspectives for using platelet-rich plasma in the treatment of knee osteoarthritis: Can it be improved through modifications of the protocol?Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2026Review
- Article
- Spin and reporting bias in the use of platelet-rich plasma for the treatment of knee osteoarthritis.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Review
- Effectiveness of therapeutic exercise and platelet-rich plasma in the case of knee osteoarthritis.Journal of physical therapy science · 2025Article
- Pain Decrement Using Radiofrequency Therapy After Knee Platelet-Rich Plasma Injections Within First 72 h in Active Populations with Patellar Chondropathy.Journal of clinical medicine · 2025Article
- Mechanisms for reducing/eliminating chronic neuropathic pain with a focus on platelet-rich plasma.Experimental biology and medicine (Maywood, N.J.) · 2025Review
- Demographic, anthropometric and intrasubject variations affect platelet-rich plasma formulation.Journal of experimental orthopaedics · 2025Article
- Infiltration therapy in the context of cartilage surgery.Archives of orthopaedic and trauma surgery · 2024Review
- Exploring Platelet-Rich Plasma Therapy for Knee Osteoarthritis: An In-Depth Analysis.Journal of functional biomaterials · 2024Review
- Efficacy of Intraoperative Platelet-Rich Plasma After Meniscal Repair: Systematic Review and Meta-analysis.Indian journal of orthopaedics · 2024Review
- Reporting Bias is Highly Prevalent in Systematic Reviews and Meta-Analyses of Platelet Rich Plasma Injections for Hip Osteoarthritis.Arthroscopy, sports medicine, and rehabilitation · 2024Review
- Addressing Knee Osteoarthritis Pathology Through Platelet-Rich Plasma Treatment: A Comprehensive Review.Advances in orthopedics · 2024Review
- Advances with Platelet-Rich Plasma for Bone Healing.Biologics : targets & therapy · 2024Review
- The Synergistic Effects of Hyaluronic Acid and Platelet-Rich Plasma for Patellar Chondropathy.Biomedicines · 2023Review
- Disease-modifying effects of orthobiologics in the treatment of knee osteoarthritis: the lesson learned from preclinical research models.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Article
- SAS-PRP Study: A Real-Life Satisfaction Assessment in Patients with Cartilage Lesions of the Knee Treated by Platelet-Rich Plasma.Bioengineering (Basel, Switzerland) · 2023Article
- Biotherapeutic Applications of Platelet-Rich Plasma in Regenerative Medicine.Tissue engineering and regenerative medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo explore the utilization of platelet-rich plasma (PRP) for degenerative cartilage processes and evaluate whether there is sufficient evidence to better define its potential effects.
designSystematic literature reviews were conducted in PubMed/MEDLINE and Cochrane electronic databases till May 2015, using the keywords "platelet-rich plasma OR PRP OR autologous conditioned plasma OR ACP AND cartilage OR chondrocyte OR chondrogenesis OR osteoarthritis (OA) OR arthritis."
resultsThe final result yielded 29 articles. Twenty-six studies examined PRP administration for knee OA and 3 involved PRP administration for hip OA. The results included 9 prospective randomized controlled trials (RCTs) (8 knee and 1 hip), 4 prospective comparative studies, 14 case series, and 2 retrospective comparative studies. Hyaluronic acid (HA) was used as a control in 11 studies (7 RCTs, 2 prospective comparative studies, and 2 retrospective cohort). Overall, all RCTs reported on improved symptoms compared to baseline scores. Only 2 RCTs-one for knee and one for hip-did not report significant superiority of PRP compared to the control group (HA). Nine out of 11 HA controlled studies showed significant better results in the PRP groups. A trend toward better results for PRP injections in patients with early knee OA and young age was observed; however, lack of uniformity was evident in terms of indications, inclusion criteria, and pathology definitions in the different studies.
conclusionCurrent clinical evidence supports the benefit in PRP treatment for knee and hip OA, proven to temporarily relieve pain and improve function of the involved joint with superior results compared with several alternative treatments. Further research to establish the optimal preparation protocol and characteristics of PRP injections for OA is needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.