ArticleHuman brain mapping2017
Important considerations in lesion-symptom mapping: Illustrations from studies of word comprehension.
Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Evidence of Motor Skill Learning in Acute Stroke Patients Without Lesions to the Thalamus and Internal Capsule.Stroke · 2022Trial
- Computational Pipeline in Clinical Connectomics.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Elucidating White Matter Contributions to the Cognitive Architecture of Affective Prosody Recognition: Evidence from Right Hemisphere Stroke.Brain sciences · 2025Article
- Linking Memory Impairment to Structural Connectivity in Extrahippocampal Temporal Lobe Epilepsy Surgery.Neurology international · 2025Article
- How Can Graph Theory Inform the Dual-stream Model of Speech Processing? A Resting-state Functional Magnetic Resonance Imaging Study of Stroke and Aphasia Symptomology.Journal of cognitive neuroscience · 2025Article
- Mary has a little chair: Eliciting noun-modifier phrases in individuals with acute post-stroke aphasia.Aphasiology · 2024Article
- A large public dataset of annotated clinical MRIs and metadata of patients with acute stroke.Scientific data · 2023Article
- Understanding Language Reorganization With Neuroimaging: How Language Adapts to Different Focal Lesions and Insights Into Clinical Applications.Frontiers in human neuroscience · 2022Review
- Anterior connectivity critical for recovery of connected speech after stroke.Brain communications · 2022Article
- Neuroanatomy of complex social emotion dysregulation in adolescent offenders.Cognitive, affective & behavioral neuroscience · 2021Article
- Effect of Stroke on Contralateral Functional Connectivity.Brain connectivity · 2021Article
- Lesion Quantification Toolkit: A MATLAB software tool for estimating grey matter damage and white matter disconnections in patients with focal brain lesions.NeuroImage. Clinical · 2021Article
- Towards metabolic disconnection - symptom mapping.Brain : a journal of neurology · 2020Article
- Dissociation between frontal and temporal-parietal contributions to connected speech in acute stroke.Brain : a journal of neurology · 2020Article
- Neural correlates of differential finger gesture imitation deficits in left hemisphere stroke.NeuroImage. Clinical · 2019Article
- Out of Context, Beyond the Face: Neuroanatomical Pathways of Emotional Face-Body Language Integration in Adolescent Offenders.Frontiers in behavioral neuroscience · 2019Article
- The role of left insula in executive set-switching: Lesion evidence from an acute stroke cohort.Cortex; a journal devoted to the study of the nervous system and behavior · 2018Article
- Where did language come from? Precursor mechanisms in nonhuman primates.Current opinion in behavioral sciences · 2018Article
- Mapping human brain lesions and their functional consequences.NeuroImage · 2018Review
- The Additional Contribution of White Matter Hyperintensity Location to Post-stroke Cognitive Impairment: Insights From a Multiple-Lesion Symptom Mapping Study.Frontiers in neuroscience · 2018Article
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9 authors.
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Abstract
Lesion-symptom mapping is an important method of identifying networks of brain regions critical for functions. However, results might be influenced substantially by the imaging modality and timing of assessment. We tested the hypothesis that brain regions found to be associated with acute language deficits depend on (1) timing of behavioral measurement, (2) imaging sequences utilized to define the "lesion" (structural abnormality only or structural plus perfusion abnormality), and (3) power of the study. We studied 191 individuals with acute left hemisphere stroke with MRI and language testing to identify areas critical for spoken word comprehension. We use the data from this study to examine the potential impact of these three variables on lesion-symptom mapping. We found that only the combination of structural and perfusion imaging within 48 h of onset identified areas where more abnormal voxels was associated with more severe acute deficits, after controlling for lesion volume and multiple comparisons. The critical area identified with this methodology was the left posterior superior temporal gyrus, consistent with other methods that have identified an important role of this area in spoken word comprehension. Results have implications for interpretation of other lesion-symptom mapping studies, as well as for understanding areas critical for auditory word comprehension in the healthy brain. We propose that lesion-symptom mapping at the acute stage of stroke addresses a different sort of question about brain-behavior relationships than lesion-symptom mapping at the chronic stage, but that timing of behavioral measurement and imaging modalities should be considered in either case. Hum Brain Mapp 38:2990-3000, 2017. © 2017 Wiley Periodicals, Inc.
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