ArticleMedical physics2017
Comparison of DCE-MRI kinetic parameters and FMISO-PET uptake parameters in head and neck cancer patients.
Article in Medical physics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- The significance of partial volume effect on the estimation of hypoxic tumour volume with [EJNMMI physics · 2024Article
- Is there a role for [Clinical and translational imaging · 2024Article
- The optimalEuropean journal of nuclear medicine and molecular imaging · 2022Article
- Hypoxia in relationship to tumor volume using hypoxia PET-imaging in head & neck cancer - A scoping review.Clinical and translational radiation oncology · 2022Article
- Dynamic Contrast Enhanced Study in Multiparametric Examination of the Prostate-Can We Make Better Use of It?Tomography (Ann Arbor, Mich.) · 2022Article
- Hypoxia Imaging As a Guide for Hypoxia-Modulated and Hypoxia-Activated Therapy.Antioxidants & redox signaling · 2022Review
- The Role of Imaging Biomarkers to Guide Pharmacological Interventions Targeting Tumor Hypoxia.Frontiers in pharmacology · 2022Review
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- Improving Tumor Hypoxia Location inRadiology. Imaging cancer · 2021Article
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- Combination of DCE-MRI and DWI in Predicting the Treatment Effect of Concurrent Chemoradiotherapy in Esophageal Carcinoma.BioMed research international · 2020Article
- Rationale for Combining Radiotherapy and Immune Checkpoint Inhibition for Patients With Hypoxic Tumors.Frontiers in immunology · 2019Review
- Effect of radiochemotherapy on T2* MRI in HNSCC and its relation to FMISO PET derived hypoxia and FDG PET.Radiation oncology (London, England) · 2018Article
- Robust and efficient pharmacokinetic parameter non-linear least squares estimation for dynamic contrast enhanced MRI of the prostate.Magnetic resonance imaging · 2018Article
- 18F-FDG-PET detects complete response to PD1-therapy in melanoma patients two weeks after therapy start.European journal of nuclear medicine and molecular imaging · 2018Article
- [EJNMMI research · 2017Article
- Molecular mechanisms of hypoxia in cancer.Clinical and translational imaging · 2017Review
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTumor hypoxia is a major cause of radiation resistance, often present in various solid tumors. Dynamic [
methodsThis study was done on head and neck cancer patients (N = 6), who were imaged dynamically with FMISO-PET and DCE-MRI on the same day. Images were registered and analyzed for kinetics on a voxel basis. FMISO-PET images were analyzed with the two-tissue compartment three rate-constant model. Additionally, tumor-to-muscle ratio (TMR) maps were evaluated. DCE-MRI was analyzed with the extended Tofts model. Voxel-wise Pearson's coefficients were calculated for each patient to assess pairwise parameter correlations.
resultsMedian correlations between FMISO uptake parameters and DCE-MRI kinetic parameters varied across the parameter pairs in the range from -0.05 to 0.71. The highest median correlation of r = 0.71 was observed for the pair V
conclusionsBased on this clinical evidence, we can conclude that the vascular fraction parameters obtained through DCE-MRI kinetic analysis or FMISO kinetic analysis measure the same biological property, while other kinetic parameters are unrelated. These results might be useful in the design of future clinical trials involving FMISO-PET/DCE-MR multimodality imaging for the assessment of tumor microenvironment.
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