ArticleBrain structure & function2017
Interhemispheric gene expression differences in the cerebral cortex of humans and macaque monkeys.
Article in Brain structure & function, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- [Research progress on genetic effects of the asymmetry of human brain structure revealed by magnetic resonance imaging].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020Pooled it
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- Heritability of gray matter volume and asymmetry in chimpanzees (Pan troglodytes) and their association to cognitive abilities and tool use.Brain structure & function · 2025Article
- Case Report: Unilateral relapsing primary central nervous system vasculitis-expanding the phenotype.Frontiers in immunology · 2025Article
- Clinical Correlation of Altered Molecular Signatures in Epileptic Human Hippocampus and Amygdala.Molecular neurobiology · 2024Article
- Evolution of Human Brain Left-Right Asymmetry: Old Genes with New Functions.Molecular biology and evolution · 2023Article
- Protein LY6E as a candidate for mediating transport of adeno-associated virus across the human blood-brain barrier.Journal of neurovirology · 2020Article
- Asymmetry in the Cytoarchitecture of the Area 44 Homolog of the Brain of the ChimpanzeeFrontiers in neuroanatomy · 2020Article
- Mapping hemispheric asymmetries of the macaque cerebral cortex during early brain development.Human brain mapping · 2020Article
- Building an Asymmetrical Brain: The Molecular Perspective.Frontiers in psychology · 2019Review
- Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
Handedness and language are two well-studied examples of asymmetrical brain function in humans. Approximately 90% of humans exhibit a right-hand preference, and the vast majority shows left-hemisphere dominance for language function. Although genetic models of human handedness and language have been proposed, the actual gene expression differences between cerebral hemispheres in humans remain to be fully defined. In the present study, gene expression profiles were examined in both hemispheres of three cortical regions involved in handedness and language in humans and their homologues in rhesus macaques: ventrolateral prefrontal cortex, posterior superior temporal cortex (STC), and primary motor cortex. Although the overall pattern of gene expression was very similar between hemispheres in both humans and macaques, weighted gene correlation network analysis revealed gene co-expression modules associated with hemisphere, which are different among the three cortical regions examined. Notably, a receptor-enriched gene module in STC was particularly associated with hemisphere and showed different expression levels between hemispheres only in humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.