Evidence map›Paper›PMID 28317001›Full record

ArticleEnvironmental science & technology letters2017

Temporal Trends in Exposure to Organophosphate Flame Retardants in the United States.

Kate Hoffman, Craig M Butt, Thomas F Webster, Emma V Preston, Stephanie C Hammel, Colleen Makey, Amelia M Lorenzo, Ellen M Cooper, Courtney Carignan, John D Meeker and 9 more

Abstract read
In one paragraph

Article in Environmental science & technology letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed.

  1. Article
  2. Article
  3. SynergisticiScience · 2026
    Article
  4. Article
  5. Article
  6. An environmentally relevant mixture of organophosphate esters induces cholesterol biosynthesis in THP-1 macrophages.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. A mixture of organophosphate esters sex-specifically impacts monocyte-macrophages in Sprague-Dawley rats.Toxicological sciences : an official journal of the Society of Toxicology · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Impact of exposure to a mixture of organophosphate esters on the adrenal glands of Sprague Dawley rats.Toxicological sciences : an official journal of the Society of Toxicology · 2025
    Article
  20. Article

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Kate HoffmanNicholas School of the Environment, Duke University , Durham, North Carolina 27708, United States.
Craig M ButtNicholas School of the Environment, Duke University , Durham, North Carolina 27708, United States.
Thomas F WebsterBoston University School of Public Heath , Boston, Massachusetts 02118, United States.
Emma V PrestonBoston University School of Public Heath , Boston, Massachusetts 02118, United States.
Stephanie C HammelNicholas School of the Environment, Duke University , Durham, North Carolina 27708, United States.
Colleen MakeyBoston University School of Public Heath , Boston, Massachusetts 02118, United States.
Amelia M LorenzoNicholas School of the Environment, Duke University , Durham, North Carolina 27708, United States.
Ellen M CooperNicholas School of the Environment, Duke University , Durham, North Carolina 27708, United States.
Courtney CarignanHarvard T. H. Chan School of Public Health , Boston, Massachusetts 02115, United States.
John D MeekerUniversity of Michigan School of Public Health , Ann Arbor, Michigan 48109, United States.
Russ HauserHarvard T. H. Chan School of Public Health , Boston, Massachusetts 02115, United States.
Adelheid SoubryEpidemiology Research Group, Department of Public Health and Primary Care, KU Leuven-University , B-3000 Leuven, Belgium.
Susan K MurphyDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Duke University Medical Center, Durham, North Carolina 27710, United States; Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, Duke University Medical Center, Durham, North Carolina 27710, United States.
Thomas M PriceDepartment of Obstetrics and Gynecology, Division of Reproductive Endocrinology, Duke University Medical Center , Durham, North Carolina 27710, United States.
Cathrine HoyoDepartment of Biological Sciences, North Carolina State University , Raleigh, North Carolina 27695, United States.
Emma MendelsohnNicholas School of the Environment, Duke University , Durham, North Carolina 27708, United States.
Johanna CongletonEnvironmental Working Group , Washington, D.C. 20009, United States.
Julie L DanielsDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.
Heather M StapletonNicholas School of the Environment, Duke University , Durham, North Carolina 27708, United States.

Funding

Zebrafish as a Detector of Organophosphate ExposureP42ES010356 · NIEHS · DUKE UNIVERSITY · PI EDWARD D LEVIN · 2000 to 2026
$56.2M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
Training Program in Environmental EpidemiologyT32ES007069 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI LADEN, FRANCINE · 1985 to 2024
$13.9M
PCBs, Phthalates and Male Reproductive HealthR01ES009718 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HAUSER, RUSS B · 1999 to 2018
$11.6M
Environmental Epidemiology in Community SettingsT32ES014562 · NIEHS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Birgit Gunhild Claus Henn · 2006 to 2026
$7.7M
Children's Exposure to Flame Retardants: Effects on Thyroid Hormone RegulationR01ES016099 · NIEHS · DUKE UNIVERSITY · PI STAPLETON, HEATHER M · 2008 to 2017
$5.0M
Project 3: Epigenomic Consequences of Early Life Environmental Tobacco Smoke P01ES022831 · NIEHS · DUKE UNIVERSITY · PI MURPHY, SUSAN KAY · 2013 to 2018
$4.1M
Maternal and Paternal Flame Retardant Exposure, Impact on Fertility and PregnancyR01ES022955 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI HAUSER, RUSS B, MEEKER, JOHN D. · 2014 to 2018
$2.9M
Measuring Human Exposure to PBDEsR01ES015829 · NIEHS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WEBSTER, THOMAS F · 2008 to 2011
$1.8M
Prenatal Exposure to Organophosphates and Associations with Child GrowthR21ES023904 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DANIELS, JULIE L · 2015 to 2016
$436k
NIEHS NIH HHS P01 ES022831NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P42 ES010356NIEHS NIH HHS R01 ES009718NIEHS NIH HHS R01 ES015829NIEHS NIH HHS R01 ES016099NIEHS NIH HHS R01 ES022955NIEHS NIH HHS R21 ES023904NIEHS NIH HHS T32 ES007069NIEHS NIH HHS T32 ES014562
6 · The paper itself

Abstract

During the past decade, use of organophosphate compounds as flame retardants and plasticizers has increased. Numerous studies investigating biomarkers (i.e., urinary metabolites) demonstrate ubiquitous human exposure and suggest that human exposure may be increasing. To formally assess temporal trends, we combined data from 14 U.S. epidemiologic studies for which our laboratory group previously assessed exposure to two commonly used organophosphate compounds, tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) and triphenyl phosphate (TPHP). Using individual-level data and samples collected between 2002 and 2015, we assessed temporal and seasonal trends in urinary bis(1,3-dichloro-2-propyl) phosphate (BDCIPP) and diphenyl phosphate (DPHP), the metabolites of TDCIPP and TPHP, respectively. Data suggest that BDCIPP concentrations have increased dramatically since 2002. Samples collected in 2014 and 2015 had BDCIPP concentrations that were more than 15 times higher than those collected in 2002 and 2003 (10

Identifiers

PMID28317001
PMCPMC5352975

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.