ReviewBioMed research international2017
Multiple Factors Involved in the Pathogenesis of White Matter Lesions.
Review in BioMed research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
85 citing papers in PubMed, 139 citations in OpenAlex.
- Spatiotemporal profiling of white matter lesions and their contribution in the pathologies of Parkinson's disease animal models.GeroScience · 2026Article
- Vascular cognitive impairment and dementia: Prevention, treatments, mechanisms and management options for the future.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- From the past to the present: evolving theories in the pathophysiology of normal pressure hydrocephalus.Journal of neurology, neurosurgery, and psychiatry · 2026Review
- Advantage of grading classification using volumetric artificial intelligence for periventricular hyperintensity and deep subcortical white matter hyperintensity.Scientific reports · 2025Article
- The differential relationship between white matter cerebrovascular perfusion and microstructure between normal cognition and mild cognitive impairment.Journal of Alzheimer's disease : JAD · 2025Article
- Stroke in Fabry Disease: Identification of Risk Factors for Stroke in a Large Single-Centre Cohort.European journal of neurology · 2025Article
- Analysis of Risk Factors for Leukoaraiosis: A Multicenter Retrospective Study.Brain and behavior · 2025Article
- Myelin basic protein and occludin may be the biomarkers to diagnose leukoaraiosis and cognitive dysfunction.Scientific reports · 2025Article
- Neuropsychiatric Symptoms and White Matter Hyperintensities in Older Cognitively Unimpaired Men Versus Women.International journal of geriatric psychiatry · 2025Article
- Clinical neurovascular coupling through cerebrovascular reserve and cognitive function.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Dementia from Small Vessel Disease Versus Alzheimer's Disease: Separate Diseases or Distinct Manifestations of Cerebral Capillopathy Due to Blood-Brain Barrier Dysfunction? A Pilot Study.International journal of molecular sciences · 2025Article
- Association between periventricular white matter hyperintensity and moderate-to-severe patients with sleep apnea syndrome.Sleep & breathing = Schlaf & Atmung · 2025Article
- Neural Correlates and Adaptive Mechanisms in Vascular Cognitive Impairment: Exploration of a Structure-Function Coupling Network.CNS neuroscience & therapeutics · 2025Article
- Asymmetric U-shaped relationship between blood glucose and white matter lesions: results of a cross-sectional study.BMC neurology · 2025Article
- White matter lesions contribute to motor and non-motor disorders in Parkinson's disease: a critical review.GeroScience · 2025Review
- Deep and periventricular white matter hyperintensities exhibit differential metabolic profiles in arteriosclerotic cerebral small vessel disease: an untargeted metabolomics study.Frontiers in neuroscience · 2025Article
- Polygenic risk for white matter hyperintensities is associated with early cerebrovascular events partly through hemodynamic measures in cognitively unimpaired middle-aged and older adults with low cardiovascular risk.Frontiers in neurology · 2025Article
- Case Report: Decoding genetic risks of vascular parkinsonism: a case series.Frontiers in genetics · 2025Article
- Association between serum uric acid levels and white matter hyperintensities in patients with mild ischemic stroke.Frontiers in neurology · 2025Article
- Association between periventricular hyperintensity or deep white matter hyperintensity and outcomes of patients with ischemic stroke.Frontiers in neurology · 2025Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
White matter lesions (WMLs), also known as leukoaraiosis (LA) or white matter hyperintensities (WMHs), are characterized mainly by hyperintensities on T2-weighted or fluid-attenuated inversion recovery (FLAIR) images. With the aging of the population and the development of imaging technology, the morbidity and diagnostic rates of WMLs are increasing annually. WMLs are not a benign process. They clinically manifest as cognitive decline and the subsequent development of dementia. Although WMLs are important, their pathogenesis is still unclear. This review elaborates on the advances in the understanding of the pathogenesis of WMLs, focusing on anatomy, cerebral blood flow autoregulation, venous collagenosis, blood brain barrier disruption, and genetic factors. In particular, the attribution of WMLs to chronic ischemia secondary to venous collagenosis and cerebral blood flow autoregulation disruption seems reasonable. With the development of gene technology, the effect of genetic factors on the pathogenesis of WMLs is gaining gradual attention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.