Evidence map›Paper›PMID 28316991›Full record

ArticleBioMed research international2017

Interferon-Gamma Release Assay Performance of Cerebrospinal Fluid and Peripheral Blood in Tuberculous Meningitis in China.

Liping Pan, Fei Liu, Jinli Zhang, Xinting Yang, Shiqi Zheng, Jing Li, Hongyan Jia, Xiaoyou Chen, Mengqiu Gao, Zongde Zhang

Abstract read
In one paragraph

Article in BioMed research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Review
  7. Article
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Liping PanBeijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, 97 Machang Road, Tongzhou District, Beijing 101149, China.ORCID 0000-0001-6172-3630
Fei LiuTuberculosis Department, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, 97 Machang Road, Tongzhou District, Beijing 101149, China.
Jinli ZhangNeurology Department, People's Liberation Army 263 Hospital, 141 Yongshun South Street, Tongzhou District, Beijing 101149, China.
Xinting YangTuberculosis Department, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, 97 Machang Road, Tongzhou District, Beijing 101149, China.
Shiqi ZhengNeurosurgery Department, Beijing Luhe Hospital, 82 Xinhua South Street, Tongzhou District, Beijing 101110, China.
Jing LiNeurology Department, People's Liberation Army 263 Hospital, 141 Yongshun South Street, Tongzhou District, Beijing 101149, China.
Hongyan JiaBeijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, 97 Machang Road, Tongzhou District, Beijing 101149, China.
Xiaoyou ChenTuberculosis Department, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, 97 Machang Road, Tongzhou District, Beijing 101149, China.
Mengqiu GaoTuberculosis Department, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, 97 Machang Road, Tongzhou District, Beijing 101149, China.
Zongde ZhangBeijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, 97 Machang Road, Tongzhou District, Beijing 101149, China.ORCID 0000-0003-0857-9793

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to examine the performance of T-SPOT.TB on cerebrospinal fluid (CSF) and peripheral blood (PB) in diagnosis of tuberculous meningitis (TBM) in China. Of 100 patients with presumed TBM prospectively enrolled from Sep 2012 to Oct 2014, 53 were TBM (21 definite and 32 probable TBM cases) and 37 were non-TBM cases; the other 10 patients were excluded from analysis due to inconclusive diagnosis, no sufficient CSF samples, or incomplete follow-up. T-SPOT.TB on CSF and PB and routine laboratory tests of CSF were performed simultaneously. The receiver operating characteristic (ROC) curve and cut-off value of CSF T-SPOT.TB and routine CSF parameters were established between TBM and non-TBM group. The area under ROC curve (AUC) of the T-SPOT.TB on CSF and PB was 0.81 and 0.89, which was higher than that of the routine CSF parameters (AUC 0.67-0.77). Although the sensitivity of CSF T-SPOT.TB was lower than that of PB T-SPOT.TB (60.8% versus 90.6%,

Indexed as

Interferon-gamma Release TestsAdultArea Under CurveChinaFemaleHumansInterferon-gammaMaleMiddle AgedProspective StudiesReproducibility of ResultsROC CurveSensitivity and SpecificityTuberculosis, MeningealYoung AdultInterferon-gamma

Identifiers

PMID28316991
PMCPMC5337854

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.