ArticleBMJ open diabetes research & care2017
Periodontitis as a possible early sign of diabetes mellitus.
Article in BMJ open diabetes research & care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03459638 (Periodontitis as a Potential Early Risk Indicator for Diabetes Mellitus, Atherosclerotic Cardiovascular Disease, Metabolic Syndrome and Obstructive Sleep Apnea Syndrome), which is not on this map. Cited by 42 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Periodontitis as a Potential Early Risk Indicator for Diabetes Mellitus, Atherosclerotic Cardiovascular Disease, Metabolic Syndrome and Obstructive Sleep Apnea Syndrome
Who cites it
42 citing papers in PubMed.
- Effect of periodontal therapy with systemic antimicrobials on parameters of metabolic syndrome: A randomized clinical trial.Journal of clinical periodontology · 2017Trial
- Changes of Periodontal Conditions of First and Second Molars With Furcation Involvement Grade II or III - a Retrospective Analysis of 14 to 17 Year Follow-up.International journal of dental hygiene · 2026Article
- Effectiveness of multi-stage diabetes screening in the dental care setting: a scoping literature review.BMC oral health · 2026Article
- Salivary biomarker profiling in prediabetes-associated periodontitis: role of adiponectin, resistin, and total matrix metalloproteinase-8.Frontiers in dental medicine · 2026Article
- Article
- Periodontal markers predict glycemic control in diabetic patients a ten year retrospective analysis.Scientific reports · 2025Article
- Continuous glucose monitoring reveals periodontitis-induced glucose variability, insulin resistance, and gut microbiota dysbiosis in mice.Scientific reports · 2025Article
- Assessment of periodontitis as a predictive sign of occurrence of type-II diabetes mellitus.The Saudi dental journal · 2025Article
- Salivary fructosamine in diabetic and non-diabetic individuals with healthy and diseased periodontium and its changes after non-surgical periodontal therapy.Acta diabetologica · 2025Article
- Risk of atopic dermatitis in periodontitis patients with and without dental scaling: A retrospective cohort study.PloS one · 2025Article
- The Role of Autophagy in the Regulation of Bidirectional Relationships in Diabetic Periodontitis.Journal of inflammation research · 2025Review
- The Prevalence of Metabolic Syndrome and Undiagnosed Diabetes in Periodontitis Patients and Non-Periodontitis Controls in a Dental School.Journal of clinical medicine · 2024Article
- Evaluating the association between gingival crevicular blood glucose levels and finger capillary blood glucose levels according to periodontal status.European journal of medical research · 2024Article
- Review
- Association of the severity and progression rate of periodontitis with systemic medication intake.Frontiers in oral health · 2024Article
- Association between periodontitis and the prevalence and prognosis of prediabetes: a population-based study.Journal of translational medicine · 2023Article
- Dental status and its correlation with polypharmacy and multimorbidity in a Swiss nursing home population: a cross-sectional study.Clinical oral investigations · 2023Article
- Prevalence and Associated Factors for Periodontal Disease among Type I and II Diabetes Mellitus Patients: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2023Article
- Functional Dentition, Chronic Periodontal Disease and Frailty in Older Adults-A Narrative Review.International journal of environmental research and public health · 2022Review
- Exploring the Feasibility of an Online Diabetes Wellness Programme among Periodontitis Patients with Type II Diabetes Mellitus during the COVID-19 Pandemic.Healthcare (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe early diagnosis of (pre)diabetes mellitus is essential for the prevention of diabetes complications. It has been suggested that gum disease (periodontitis) might be an early complication of diabetes and may be a useful risk indicator for diabetes screening. Therefore, a dental office could be a good location for screening for (pre)diabetes in patients with periodontitis using a validated glycated hemoglobin (HbA1c) dry spot analysis. RESEARCH DESIGN AND
methodsA total of 313 individuals from a university dental clinic participated. From 126 patients with mild/moderate periodontitis, 78 patients with severe periodontitis and 109 subjects without periodontitis, HbA1c values were obtained by the analysis of dry blood spots. Differences in mean HbA1c values and the prevalence of (pre)diabetes between the groups were analyzed.
resultsThe mild/moderate and severe periodontitis groups showed significantly higher HbA1c values (6.1%±1.4% (43 mmol/mol±15 mmol/mol) and 6.3%±1.3% (45 mmol/mol±15 mmol/mol), respectively) compared with the control group (5.7%±0.7% (39 mmol/mol±8 mmol/mol), p=0.003). In addition, according to the American Diabetes Association (ADA) guidelines for diagnosis, there was a significant over-representation of subjects with suspected diabetes (23% and 14%) and pre-diabetes (47% and 46%) in the severe periodontitis group and mild/moderate periodontitis groups, respectively, compared with the control group (10% and 37%, p=0.010). Notably, 18.1% of patients with suspected new diabetes were found among subjects with severe periodontitis compared with 9.9% and 8.5% among subjects with mild/moderate periodontitis and controls, respectively (p=0.024).
conclusionsThe dental office, with particular focus on patients with severe periodontitis, proved to be a suitable location for screening for (pre)diabetes; a considerable number of suspected new diabetes cases were identified. The early diagnosis and treatment of (pre)diabetes help to prevent more severe complications and benefit the treatment of periodontitis.
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