ArticleFrontiers in genetics2017
Integrative Approaches for Studying Mitochondrial and Nuclear Genome Co-evolution in Oxidative Phosphorylation.
Article in Frontiers in genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 74 citations in OpenAlex.
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- The complete mitochondrial genome of Sinojackia microcarpa: evolutionary insights and gene transfer.BMC genomics · 2025Article
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- Mutation pressure mediates a pattern of substitution rates with latitude and climate in carnivores.Ecology and evolution · 2024Article
- Conservation Mitonuclear Replacement: Facilitated mitochondrial adaptation for a changing world.Evolutionary applications · 2024Article
- Positive regulation of oxidative phosphorylation by nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice.Nature communications · 2023Article
- Different waves of postglacial recolonisation and genomic structure of bank vole populations in NE Poland.Heredity · 2023Article
- Mito-nuclear selection induces a trade-off between species ecological dominance and evolutionary lifespan.Nature ecology & evolution · 2022Article
- Positive selection over the mitochondrial genome and its role in the diversification of gentoo penguins in response to adaptation in isolation.Scientific reports · 2022Article
- The role of mitonuclear incompatibilities in allopatric speciation.Cellular and molecular life sciences : CMLS · 2022Review
- Aging: All roads lead to mitochondria.Seminars in cell & developmental biology · 2021Article
- Pervasive Mitonuclear Coadaptation Underlies Fast Development in Interpopulation Hybrids of a Marine Crustacean.Genome biology and evolution · 2021Article
- MitImpact 3: modeling the residue interaction network of the Respiratory Chain subunits.Nucleic acids research · 2021Article
- Episodic evolution of coadapted sets of amino acid sites in mitochondrial proteins.PLoS genetics · 2021Article
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- The role of selection in the evolution of marine turtles mitogenomes.Scientific reports · 2020Article
- Genetic hitchhiking, mitonuclear coadaptation, and the origins of mt DNA barcode gaps.Ecology and evolution · 2020Article
- Mitonuclear genomics and aging.Human genetics · 2020Review
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5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In animals, interactions among gene products of mitochondrial and nuclear genomes (mitonuclear interactions) are of profound fitness, evolutionary, and ecological significance. Most fundamentally, the oxidative phosphorylation (OXPHOS) complexes responsible for cellular bioenergetics are formed by the direct interactions of 13 mitochondrial-encoded and ∼80 nuclear-encoded protein subunits in most animals. It is expected that organisms will develop genomic architecture that facilitates co-adaptation of these mitonuclear interactions and enhances biochemical efficiency of OXPHOS complexes. In this perspective, we present principles and approaches to understanding the co-evolution of these interactions, with a novel focus on how genomic architecture might facilitate it. We advocate that recent interdisciplinary advances assist in the consolidation of links between genotype and phenotype. For example, advances in genomics allow us to unravel signatures of selection in mitochondrial and nuclear OXPHOS genes at population-relevant scales, while newly published complete atomic-resolution structures of the OXPHOS machinery enable more robust predictions of how these genes interact epistatically and co-evolutionarily. We use three case studies to show how integrative approaches have improved the understanding of mitonuclear interactions in OXPHOS, namely those driving high-altitude adaptation in bar-headed geese, allopatric population divergence in
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