ArticleFrontiers in neurology2017
A Postural Tremor Highly Responsive to Transcranial Cerebello-Cerebral DCS in ARCA3.
Article in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Effects of Anodal Cerebellar Transcranial Direct Current Stimulation on Movements in Patients with Cerebellar Ataxias: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Autosomal recessive spino-cerebellar ataxia type 10 (SCAR10): clinical presentation associated with c.289delA ANO10 gene variant.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- ANO10 Function in Health and Disease.Cerebellum (London, England) · 2023Review
- Review
- A Brief History of Cerebellar Neurostimulation.Cerebellum (London, England) · 2022Review
- A narrative review on non-invasive stimulation of the cerebellum in neurological diseases.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Review
- Epidural cerebellar stimulation drives widespread neural synchrony in the intact and stroke perilesional cortex.Journal of neuroengineering and rehabilitation · 2021Article
- The neurological update: therapies for cerebellar ataxias in 2020.Journal of neurology · 2020Review
- The role of the cerebellum in degenerative ataxias and essential tremor: Insights from noninvasive modulation of cerebellar activity.Movement disorders : official journal of the Movement Disorder Society · 2020Review
- Non-invasive Transcranial Electrical Stimulation in Movement Disorders.Frontiers in neuroscience · 2020Review
- Consensus Paper: Experimental Neurostimulation of the Cerebellum.Cerebellum (London, England) · 2019Review
- Cerebellar transcranial direct current stimulation in spinocerebellar ataxia type 3 (SCA3-tDCS): rationale and protocol of a randomized, double-blind, sham-controlled study.BMC neurology · 2019Article
- Long term at-home treatment with transcranial direct current stimulation (tDCS) improves symptoms of cerebellar ataxia: a case report.Journal of neuroengineering and rehabilitation · 2019Article
- ANO10 mutational screening in recessive ataxia: genetic findings and refinement of the clinical phenotype.Journal of neurology · 2019Observational
- Noninvasive Cerebellar Stimulation as a Complement Tool to Pharmacotherapy.Current neuropharmacology · 2019Review
- Cerebellar Cortex as a Therapeutic Target for Neurostimulation.Cerebellum (London, England) · 2018Review
- Non-invasive Cerebellar Stimulation: Moving Towards Clinical Applications for Cerebellar and Extra-Cerebellar Disorders.Cerebellum (London, England) · 2018Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesCerebellar ataxias are disabling disorders that impact the quality of life of patients. In many cases, an effective treatment is missing. Despite the increasing knowledge on the pathogenesis of cerebellar disorders including genetic aspects, there is currently a gap in the therapeutical management of cerebellar deficits. Cerebellar ataxia associated with ANO10 mutation (ARCA3) presents a disabling cerebellar syndrome. The aim of this study is to report a patient with a marked postural tremor responding to transcranial cerebello-cerebral direct current stimulation (tCCDCS).
methodsWe applied tCCDCS using anodal stimulation over the cerebellum with a return electrode on the contralateral motor cortex. We performed a clinical rating, accelerometry studies, and recordings of voluntary movements at baseline, after sham, and after active tCCDCS.
resultsA dramatic response of postural tremor was observed after tCCDCS, with a major drop of the power spectral density to 26.12% of basal values. DISCUSSION: The postural tremor of cerebellar ataxia associated with ANO10 mutation was highly responsive to tCCDCS in our patient. This case illustrates that tCCDCS is a novel therapeutic option in the treatment of cerebellar deficits and might represent a promising tool to reduce tremor in ARCA3.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.