Evidence map›Paper›PMID 28316456›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2017

Functional Connectivity of the Pedunculopontine Nucleus and Surrounding Region in Parkinson's Disease.

Ashwani Jha, Vladimir Litvak, Samu Taulu, Wesley Thevathasan, Jonathan A Hyam, Tom Foltynie, Patricia Limousin, Marko Bogdanovic, Ludvic Zrinzo, Alexander L Green and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ashwani JhaSobell Department of Motor Neuroscience, UCL Institute of Neurology, Queen Square, London, UK.
Vladimir LitvakSobell Department of Motor Neuroscience, UCL Institute of Neurology, Queen Square, London, UK.
Samu TauluI-LABS MEG Brain Imaging Center, University of Washington, Seattle, WA, USA.
Wesley ThevathasanNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Jonathan A HyamUnit of Functional Neurosurgery, UCL Institute of Neurology, Queen Square, London, UK.
Tom FoltynieSobell Department of Motor Neuroscience, UCL Institute of Neurology, Queen Square, London, UK.
Patricia LimousinSobell Department of Motor Neuroscience, UCL Institute of Neurology, Queen Square, London, UK.
Marko BogdanovicNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Ludvic ZrinzoSobell Department of Motor Neuroscience, UCL Institute of Neurology, Queen Square, London, UK.
Alexander L GreenNuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Tipu Z AzizNuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Karl FristonWellcome Trust Centre for Neuroimaging, 12 Queen Square, London, UK.
Peter BrownNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

Funding

Medical Research Council MC_UU_12024/1Medical Research Council MR/K005464/1Wellcome Trust 091593
6 · The paper itself

Abstract

Deep brain stimulation of the pedunculopontine nucleus and surrounding region (PPNR) is a novel treatment strategy for gait freezing in Parkinson's disease (PD). However, clinical results have been variable, in part because of the paucity of functional information that might help guide selection of the optimal surgical target. In this study, we use simultaneous magnetoencephalography and local field recordings from the PPNR in seven PD patients, to characterize functional connectivity with distant brain areas at rest. The PPNR was preferentially coupled to brainstem and cingulate regions in the alpha frequency (8-12 Hz) band and to the medial motor strip and neighboring areas in the beta (18-33 Hz) band. The distribution of coupling also depended on the vertical distance of the electrode from the pontomesencephalic line: most effects being greatest in the middle PPNR, which may correspond to the caudal pars dissipata of the pedunculopontine nucleus. These observations confirm the crucial position of the PPNR as a functional node between cortical areas such as the cingulate/ medial motor strip and other brainstem nuclei, particularly in the dorsal pons. In particular they suggest a special role for the middle PPNR as this has the greatest functional connectivity with other brain regions.

Indexed as

AgedAlpha RhythmBeta RhythmBrainGyrus CinguliHumansMagnetoencephalographyMaleMiddle AgedMotor CortexNeural PathwaysParkinson DiseasePedunculopontine Tegmental Nucleuscoherencedeep brain stimulation (DBS)gait freezinghumanmagnetoencephalography (MEG)oscillationspedunculopontine nucleus

Identifiers

PMID28316456
PMCPMC5357066

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.