Evidence map›Paper›PMID 28316378›Full record

ArticleMediators of inflammation2017

High Neutrophil-to-Lymphocyte Ratio Predicts Cardiovascular Mortality in Chronic Hemodialysis Patients.

Han Li, Xiangxue Lu, Ruifang Xiong, Shixiang Wang

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04238338 (Association of Monocyte / Lymphocyte Ratio With Risk of Death and Cardiovascular Events in Peritoneal Dialysis Patients), which is not on this map. Cited by 51 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 3 pooled it
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04238338 unknown statusnot on this mapstarted 2020, after this paper: background citation

Association of Monocyte / Lymphocyte Ratio With Risk of Death and Cardiovascular Events in Peritoneal Dialysis Patients

TypeobservationalSponsorZhujiang HospitalRan2020 to 2022Enrolled266ConditionsPeritoneal Dialysis, InflammationArmsmonocyte / lymphocyte ratio
3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 3 syntheses or guidelines pooled it, 98 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Han LiDepartment of Blood Purification, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China; Nephrology Faculty, Capital Medical University, Beijing, China.ORCID 0000-0003-2869-6911
Xiangxue LuDepartment of Blood Purification, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China; Nephrology Faculty, Capital Medical University, Beijing, China.ORCID 0000-0003-3528-582X
Ruifang XiongDepartment of Blood Purification, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China; Nephrology Faculty, Capital Medical University, Beijing, China.
Shixiang WangDepartment of Blood Purification, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China; Nephrology Faculty, Capital Medical University, Beijing, China.ORCID 0000-0002-5500-4119
Capital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The neutrophil-to-lymphocyte ratio (NLR) is a novel simple biomarker of inflammation. It has emerged as a predictor of poor prognosis in cancer and cardiovascular disease in general population. But little was known of its prognostic value in chronic hemodialysis (HD) patients. Here we investigated the association between NLR and cardiovascular risk markers, including increased pulse pressure (PP), left ventricular mass index (LVMI) and intima-media thickness (IMT), and mortality in HD patients. Two hundred and sixty-eight HD patients were enrolled in this study and were followed for 36 months. The primary end point was all-cause mortality and cardiovascular mortality. Multivariable Cox regression was used to calculate the adjusted hazard ratios for NLR on all-cause and cardiovascular survival. We pinpointed that higher NLR in HD patients was a predictor of increased PP, LVMI, and IMT; HD patients with higher NLR had a lower survival at the end of the study; furthermore, high NLR was an independent predictor of all-cause and cardiovascular mortality when adjusted for other risk factors. In conclusion, higher NLR in HD patients was associated with cardiovascular risk factors and mortality.

Indexed as

Renal DialysisAdultAgedCardiovascular DiseasesCarotid Intima-Media ThicknessFemaleHumansLymphocytesMaleMiddle AgedNeutrophilsProportional Hazards ModelsRisk FactorsYoung Adult

Identifiers

PMID28316378
PMCPMC5339486
OpenAlexW2589366056

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.