Evidence map›Paper›PMID 28316249›Full record

ArticleAmyotrophic lateral sclerosis & frontotemporal degeneration2017

Association of fractures with the incidence of amyotrophic lateral sclerosis.

Tracy L Peters, Caroline E Weibull, Fang Fang, Dale P Sandler, Paul C Lambert, Weimin Ye, Freya Kamel

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Amyotrophic lateral sclerosis & frontotemporal degeneration, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Structural and functional properties of bone are compromised in amyotrophic lateral sclerosis mice.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2018
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Tracy L Petersa Department of Medical Epidemiology and Biostatistics , Karolinska Institutet , Stockholm , Sweden.
Caroline E Weibulla Department of Medical Epidemiology and Biostatistics , Karolinska Institutet , Stockholm , Sweden.
Fang Fanga Department of Medical Epidemiology and Biostatistics , Karolinska Institutet , Stockholm , Sweden.
Dale P Sandlerb Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park , NC , USA , and.
Paul C Lamberta Department of Medical Epidemiology and Biostatistics , Karolinska Institutet , Stockholm , Sweden.
Weimin Yea Department of Medical Epidemiology and Biostatistics , Karolinska Institutet , Stockholm , Sweden.
Freya Kamelb Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park , NC , USA , and.
Karolinska Institutet · SENational Institute of Environmental Health Sciences · US

Funding

Environmental Exposures And Risk For Cancer and Chronic Diseases In AdultsZIAES049028 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SANDLER, DALE P · 2009 to 2024
$1.6M
Lead And Other Neurotoxins As Risk Factors For Amyotrophic Lateral SclerosisZIAES049005 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SANDLER, DALE P · 2009 to 2017
$718k
LEAD AND OTHER NEUROTOXINS AS RISK FACTORS FOR AMYOTROPHIC LATERAL SCLEROSISZ01ES049005 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SANDLER, DALE P · 1992 to 2008
$158k
Intramural NIH HHS Z01 ES049005
6 · The paper itself

Abstract

objectiveElevated bone turnover observed in ALS patients suggests poor bone health and increased fracture risk. We therefore evaluated the relationship of fracture to subsequent ALS risk.

methodsWe followed 4,529,460 Swedes from 1987 to 2010 and identified ALS and fractures from the Swedish National Patient Register. We examined associations of ALS risk with all fractures, osteoporotic and non-osteoporotic fractures, and traumatic and non-traumatic fractures among individuals aged 30-80 years. We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). We analysed the association of ALS with time since fracture using a Poisson regression model.

resultsAll fractures (HR: 1.51, 95% CI 1.39-1.65) as well as osteoporotic (HR: 1.59, 95% CI 1.41-1.79), non-osteoporotic (HR: 1.46, 95% CI 1.31-1.63), traumatic (HR: 1.50, 95% CI 1.37-1.63), and non-traumatic (HR: 1.80, 95% CI 1.35-2.40) fractures were associated with a higher incidence of ALS. Increased ALS incidence was associated with fractures occurring from one (HR: 2.33, 95% CI 2.04-2.66) to 18 (HR: 1.19, 95% CI 1.01-1.43) years before ALS diagnosis.

conclusionsPoor bone health may be related to ALS. These findings may offer insight into ALS pathophysiology.

Indexed as

AgedAmyotrophic Lateral SclerosisCohort StudiesFemaleFractures, BoneHumansIncidenceMaleMiddle AgedProspective StudiesRegistriesRisk FactorsSwedenAmyotrophic lateral sclerosiscohort studyfracturesrisk factors

Identifiers

PMID28316249
PMCPMC5527744
OpenAlexW2601003545

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.