Evidence map›Paper›PMID 28316052›Full record

ReviewCurrent hypertension reports2017

The Gut Microbiome, Energy Homeostasis, and Implications for Hypertension.

Ruth A Riedl, Samantha N Atkinson, Colin M L Burnett, Justin L Grobe, John R Kirby

Open access · greenAbstract readReview
In one paragraph

Review in Current hypertension reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 57 citations in OpenAlex.

  1. Trial
  2. Effects of Totum-63 on glucose homeostasis and postprandial glycemia: a translational study.American journal of physiology. Endocrinology and metabolism · 2021
    Trial
  3. Review
  4. Article
  5. Reutericyclin mitigates risperidone-induced suppression of anaerobic energy expenditure.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Perspective: Obesity-an unexplained epidemic.The American journal of clinical nutrition · 2022
    Article
  18. Methods for the ComprehensiveFrontiers in physiology · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ruth A RiedlDepartment of Pharmacology, University of Iowa, 51 Newton Rd., 2-307 BSB, Iowa City, IA, 52242, USA.
Samantha N AtkinsonDepartment of Informatics, subtract Bioinformatics, University of Iowa, Iowa City, IA, USA.
Colin M L BurnettDepartment of Internal Medicine, University of Iowa, Iowa City, IA, USA.
Justin L GrobeDepartment of Pharmacology, University of Iowa, 51 Newton Rd., 2-307 BSB, Iowa City, IA, 52242, USA. justin-grobe@uiowa.edu.
John R KirbyDepartment of Microbiology, University of Iowa, Iowa City, IA, USA. jkirby@mcw.edu.
University of Iowa · USMedical College of Wisconsin · US

Funding

Role of the brain Renin-Angiotensin Sys. in Cardiovas and Metabolic RegulationP01HL084207 · NHLBI · UNIVERSITY OF IOWA · PI GROBE, JUSTIN L · 2007 to 2022
$30.2M
Interaction between leptin and angiotensin in the pathogenesis of obesity-hypertensionR01HL134850 · NHLBI · UNIVERSITY OF IOWA · PI Justin L Grobe · 2017 to 2026
$4.4M
SHORT-TERM TRAINING: STUDENTS IN HEALTH PROF. SCHOOLST35HL007485 · NHLBI · UNIVERSITY OF IOWA · PI ROGHAIR, ROBERT D · 1985 to 2019
$4.3M
Lysine Acetylation in N. gonorrhoeae Quorum Sensing and Biofilm FormationR01AI108255 · NIAID · UNIVERSITY OF IOWA · PI KIRBY, JOHN R, SCHILLING, BIRGIT · 2014 to 2018
$4.1M
Central Renin-Angiotensin System: Metabolism, Fluid Balance, and HypertensionR00HL098276 · NHLBI · UNIVERSITY OF IOWA · PI GROBE, JUSTIN L · 2012 to 2014
$715k
Central Renin-Angiotensin System: Metabolism, Fluid Balance, and HypertensionK99HL098276 · NHLBI · UNIVERSITY OF IOWA · PI GROBE, JUSTIN L · 2010 to 2011
$214k
NHLBI NIH HHS K99 HL098276NHLBI NIH HHS P01 HL084207NHLBI NIH HHS R00 HL098276NHLBI NIH HHS R01 HL134850NHLBI NIH HHS T35 HL007485NIAID NIH HHS R01 AI108255
6 · The paper itself

Abstract

purpose of reviewThe influence of gut bacteria upon host physiology is increasingly recognized, but mechanistic links are lacking. Diseases of energetic imbalance such as obesity and diabetes represent major risk factors for cardiovascular diseases such as hypertension. Thus, here, we review current mechanistic contributions of the gut microbiota to host energetics. RECENT

findingsGut bacteria generate a multitude of small molecules which can signal to host tissues within and beyond the gastrointestinal tract to influence host physiology, and gut bacteria can also influence host digestive efficiency by altering the bioavailability of polysaccharides, yet the quantitative energetic effects of these processes remain unclear. Recently, our team has demonstrated that gut bacteria constitute a major anaerobic thermogenic biomass, which can quantitatively account for obesity. Quantitative understanding of the mechanisms by which gut bacteria influence energy homeostasis may ultimately inform the relationship between gut bacteria and cardiovascular dysfunction.

Indexed as

Gastrointestinal MicrobiomeHomeostasisHypertensionAnimalsCardiovascular DiseasesGastrointestinal TractHumansObesityBacteriaEnergeticsEnergyMetabolismMicrobiomeMicrobiota

Identifiers

PMID28316052
PMCPMC5773096
OpenAlexW2596322156

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.