ArticleLipids2017
Trans Fatty Acids Suppress TNF-α-Induced Inflammatory Gene Expression in Endothelial (HUVEC) and Hepatocellular Carcinoma (HepG2) Cells.
Article in Lipids, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Impact of Dairy Intake on Plasma FNutrients · 2021Trial
- A phase IIb randomized placebo-controlled trial testing the effect of MAG-EPA long-chain omega-3 fatty acid dietary supplement on prostate cancer proliferation.Communications medicine · 2024Article
- Allele-specific effect of various dietary fatty acids and ETS1 transcription factor on SCD1 expression.Scientific reports · 2024Article
- Role of Stearoyl-CoA Desaturase 1 in Cardiovascular Physiology.International journal of molecular sciences · 2023Review
- C57bl/6 Mice Show Equivalent Taste Preferences toward Ruminant and Industrial Trans Fatty Acids.Nutrients · 2023Article
- The Modulatory Effects of Fatty Acids on Cancer Progression.Biomedicines · 2023Review
- Conjugated Linoleic Acids Have Anti-Inflammatory Effects in Cultured Endothelial Cells.International journal of molecular sciences · 2023Article
- Omega-9 fatty acids: potential roles in inflammation and cancer management.Journal, genetic engineering & biotechnology · 2022Review
- The Effect of Trans Fatty Acids on Human Health: Regulation and Consumption Patterns.Foods (Basel, Switzerland) · 2021Review
- Differential Effects of Ruminant and Industrial 18-CarbonMolecules (Basel, Switzerland) · 2021Article
- Comparative transcriptome and microbiota analyses provide new insights into the adverse effects of industrial trans fatty acids on the small intestine of C57BL/6 mice.European journal of nutrition · 2021Article
- Dietary Fat and Cancer-Which Is Good, Which Is Bad, and the Body of Evidence.International journal of molecular sciences · 2020Review
- Mechanisms of Action of trans Fatty Acids.Advances in nutrition (Bethesda, Md.) · 2020Review
- The effect of trans-palmitoleic acid on cell viability and sirtuin 1 gene expression in hepatocytes and the activity of peroxisome-proliferator-activated receptor-alpha.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2020Article
- The Regulation of Lipokines by Environmental Factors.Nutrients · 2019Review
- Cellular and molecular effects of Baccharis dracunculifolia D.C. and Plectranthus barbatus Andrews medicinal plant extracts on retinoid metabolism in the human hepatic stellate cell LX-2.BMC complementary and alternative medicine · 2019Article
- Omega-3 Fatty Acids Survey in Men under Active Surveillance for Prostate Cancer: from Intake to Prostate Tissue Level.Nutrients · 2019Observational
- Intermittent Hypoxia Up-RegulatesInternational journal of molecular sciences · 2019Article
- Milk fat components with potential anticancer activity-a review.Bioscience reports · 2017Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trans fatty acids (TFA) intake has been linked to cardiovascular diseases and liver diseases; yet the effect of TFA on inflammation remains controversial. Accordingly, the objective of this paper was to determine the in vitro effects of TFA on inflammatory gene expression. Human umbilical vein endothelial cells (HUVEC) and human hepatocellular carcinoma (HepG2) cells were treated for 24 h with either trans-vaccenic acid (tVA), trans-palmitoleic acid (tPA) or elaidic acid (EA) at concentrations of 5-150 µM, or with a mixture of tVA and tPA (150/50 µM). All TFA were highly incorporated into cell membranes, as determined by gas chromatography, representing 15-20% of total fatty acids in HUVEC and 3-8% in HepG2 cells. Incorporation of EA, a common industrial TFA, increased the ratio of the stearoyl-CoA desaturase (SCD-1), a key enzyme involved in fatty acid metabolism. Ruminant TFA, including tVA, tPA and the mixture of tVA and tPA, significantly reduced the TNF-α-induced gene expression of TNF, VCAM-1 and SOD2 in HUVEC, as well as TNF and IL-8 in HepG2 cells. EA also decreased inflammatory gene expression in HUVEC, but not in HepG2 cells. The inhibition of peroxisome proliferator-activated receptor (PPAR)-γ did not influence the effects of TFA on gene expression. Overall, physiological and supraphysiological concentrations of TFA, especially tVA and tPA, prevented inflammatory gene expression in vitro. This effect is independent of PPAR-γ activation and may be due to an alteration of fatty acid metabolism in cell membranes caused by the high incorporation of TFA.
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Registered trials
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