ArticleDevelopmental neuroscience2016
Cerebrospinal Fluid and Parenchymal Brain Development and Growth in the Healthy Fetus.
Article in Developmental neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Donor human milk and structural brain development in very preterm infants.Pediatric research · 2026Observational
- Nested Fluid-Structure Interaction Predictive Modeling of Fetal Brain Stress During Maternal Trauma.Biology · 2026Article
- An end-to-end pipeline for automated fetal brain segmentation and biometry from 3D SSFP MRI.Frontiers in neuroscience · 2026Article
- Early parenteral lipid intake supports cerebellar neurometabolism at term-age in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2025Observational
- Burst of gyrification in the human brain after birth.Communications biology · 2025Article
- Neurodevelopmental Outcomes of Preschoolers with Antenatal Zika Virus Exposure Born in the United States.Pathogens (Basel, Switzerland) · 2024Article
- MR insights into fetal brain development: what is normal and what is not.Pediatric radiology · 2024Review
- Experience of early-life pain in premature infants is associated with atypical cerebellar development and later neurodevelopmental deficits.BMC medicine · 2023Article
- Hippocampal rotation is associated with ventricular atrial size.Pediatric radiology · 2023Article
- Impaired in vivo feto-placental development is associated with neonatal neurobehavioral outcomes.Pediatric research · 2023Article
- Robust sex differences in functional brain connectivity are present in utero.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Maternal psychological distress during the COVID-19 pandemic and structural changes of the human fetal brain.Communications medicine · 2022Article
- Physiologically based pharmacokinetic/pharmacodynamic model for the prediction of morphine brain disposition and analgesia in adults and children.PLoS computational biology · 2021Article
- A Focus on the Cerebellum: From Embryogenesis to an Age-Related Clinical Perspective.Frontiers in systems neuroscience · 2021Review
- Development of a physiologically-based pharmacokinetic pediatric brain model for prediction of cerebrospinal fluid drug concentrations and the influence of meningitis.PLoS computational biology · 2019Article
- Brain and CSF Volumes in Fetuses and Neonates with Antenatal Diagnosis of Critical Congenital Heart Disease: A Longitudinal MRI Study.AJNR. American journal of neuroradiology · 2019Article
- Visualization of the periventricular Virchow-Robin spaces with ependymal openings.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Article
- Phenotypic spectrum of maternally inherited Leigh Syndrome associated with the m.8993T>G variant.Molecular genetics and metabolism reports · 2018Article
- Congenital Aqueductal Stenosis: Findings at Fetal MRI That Accurately Predict a Postnatal Diagnosis.AJNR. American journal of neuroradiology · 2018Article
- Systematic review and meta-analysis of MRI-based sex differences in the human fetal brain.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
objectiveThe objective of this study was to apply quantitative magnetic resonance imaging to characterize absolute cerebrospinal fluid (CSF) development, as well as its relative development to fetal brain parenchyma in the healthy human fetus.
designWe created three-dimensional high-resolution reconstructions of the developing brain for healthy fetuses between 18 and 40 weeks' gestation, segmented the parenchymal and CSF spaces, and calculated the volumes for the lateral, third, and fourth ventricles; extra-axial CSF space; and the cerebrum, cerebellum, and brainstem. From these data, we constructed normograms of the resulting volumes according to gestational age and described the relative development of CSF to fetal brain parenchyma.
resultsEach CSF space demonstrated major increases in volumetric growth during the second half of gestation: third ventricle (23-fold), extra-axial CSF (11-fold), fourth ventricle (8-fold), and lateral ventricle (2-fold). Total CSF volume was related to total brain volume (p < 0.01), as was lateral ventricle to cerebral volume (p < 0.01); however, the fourth ventricle was not related to cerebellar or brainstem volume (p = 0.18-0.19). RELEVANCE: Abnormalities of the CSF spaces are the most common anomalies of neurologic development detected on fetal screening using neurosonography. Normative values of absolute CSF volume, as well as relative growth in comparison to intracranial parenchyma, provide valuable insight into normal fetal neurodevelopment. These data may provide important biomarkers of early deviations from normal growth, better distinguish between benign variants and early disease, and serve as reference standards for postnatal growth and development in the premature infant.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.