Evidence map›Paper›PMID 28315846›Full record

Observational studyJournal of neurology, neurosurgery, and psychiatry2017

Risk factors for early psychosis in PD: insights from the Parkinson's Progression Markers Initiative.

Dominic H Ffytche, Joana B Pereira, Clive Ballard, K Ray Chaudhuri, Daniel Weintraub, Dag Aarsland

Registry-linked trialOpen access · hybridAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of neurology, neurosurgery, and psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05483036 (Perception in Parkinson's Disease), which is not on this map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05483036 completednot on this mapstarted 2022, after this paper: background citation

Perception in Parkinson's Disease

TypeobservationalSponsorBoston University Charles River CampusRan2022 to 2025Enrolled54ConditionsParkinson's Disease, Perception, Visual Hallucination
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Treatment of Parkinson's Disease-Related Psychosis.Clinical pharmacology : advances and applications · 2026
    Review
  7. Article
  8. Observational
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Cognitive Correlates of Visual and Minor Hallucinations in Parkinson's Disease.The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 5 countries.

Dominic H FfytcheKCL-PARCOG Group, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Joana B PereiraDepartment of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.
Clive BallardKCL-PARCOG Group, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
K Ray ChaudhuriKCL-PARCOG Group, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Daniel WeintraubKCL-PARCOG Group, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Dag AarslandKCL-PARCOG Group, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
King's College London · GBKarolinska Institutet · SEUniversity of Pennsylvania · US

Funding

Project IV: "Alpha-Synuclein Strains & Diverse Synucleinopathies"P50NS053488 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI TROJANOWSKI, JOHN Q. · 2007 to 2017
$20.9M
Department of Health RP-PG-0610-10100NINDS NIH HHS P50 NS053488
6 · The paper itself

Abstract

backgroundParkinson's Disease (PD) psychosis refers to the spectrum of illusions, formed hallucinations and delusions that occur in PD. Visual hallucinations and illusions are thought to be caused by specific cognitive and higher visual function deficits and patients who develop such symptoms early in the disease course have greater rates of cognitive decline and progression to dementia. To date, no studies have investigated whether such deficits are found prior to the onset of PD psychosis.

methodHere we compare baseline cognitive, biomarker (structural imaging and cerebrospinal fluid) and other PD psychosis risk factor data in patients who go on to develop illusions or hallucinations within 3-4 years of follow-up in the Parkinson's Progression Markers Initiative cohort of newly diagnosed PD.

resultsOf n=423 patients with PD, n=115 (27%) reported predominantly illusions with the median time of onset at 19.5 months follow-up. At study entry these patients had reduced CSF amyloid Aß

conclusionsThe findings suggest early onset illusions and formed hallucinations are linked to amyloid pathology in PD and point to a difference in the underlying pathophysiological mechanism of illusions and formed hallucinations, with implications for their respective links to future cognitive decline.

Indexed as

AdultAgedAmyloid beta-PeptidesCohort StudiesDelusionsDementiaDisease ProgressionFemaleFollow-Up StudiesHallucinationsHumansMaleMiddle AgedParkinson DiseasePeptide FragmentsPsychotic DisordersAmyloid beta-Peptidesamyloid beta-protein (1-42)Peptide Fragments

Identifiers

PMID28315846
PMCPMC5362125
OpenAlexW2595652832

What OpenQuestion holds

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LicenceTDM
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.