ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2017
Comparison of Atipamezole with Yohimbine for Antagonism of Xylazine in Mice Anesthetized with Ketamine and Xylazine.
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
26 citing papers in PubMed, 48 citations in OpenAlex.
- Pharmacologic Reversal of Xylazine-Induced Unconsciousness in Rats.Anesthesia and analgesia · 2026Article
- Optimization of Ketamine/Xylazine Anesthesia in Geriatric Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Anesthetic effects of a mixture of xylazine, ketamine, and buprenorphine in laboratory rats subjected to short surgical procedures.Open veterinary journal · 2025Article
- Xylazine-Associated Wounds of the Upper Extremity: Evaluation and Algorithmic Surgical Strategy.Journal of hand surgery global online · 2024Review
- Sedation Efficacy of Midazolam in Conjunction with Ketamine and Alfaxalone in Female Laboratory Guinea Pigs (Journal of the American Association for Laboratory Animal Science : JAALAS · 2024Article
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- The sleep quality- and myopia-linked PDE11A-Y727C variant impacts neural physiology by reducing catalytic activity and altering subcellular compartmentalization of the enzyme.bioRxiv : the preprint server for biology · 2023Article
- Review
- Foreign body ingestion due to detachment of pill dispenser tips in cats: a retrospective study of 13 cases.Journal of feline medicine and surgery · 2023Article
- Myopia control in Mendelian forms of myopia.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2023Article
- Fig latex inhibits the growth of pathogenic bacteria invading human diabetic wounds and accelerates wound closure in diabetic mice.Scientific reports · 2022Article
- Dexmedetomidine Effectively Sedates Asian Elephants (Animals : an open access journal from MDPI · 2022Article
- Effective Field Immobilisation and Capture of Giraffe (Animals : an open access journal from MDPI · 2022Article
- Recommended doses of medetomidine-midazolam-butorphanol with atipamezole for preventing hypothermia in mice.The Journal of veterinary medical science · 2022Article
- Article
- Mouse Anesthesia: The Art and Science.ILAR journal · 2021Review
- Altered Ocular Fibrillin Microfibril Composition in Mice With a Glaucoma-Causing Mutation of Adamts10.Investigative ophthalmology & visual science · 2021Article
- Development of an improved anesthesia protocol to increase CF1 mice survival in a portal vein infection withHeliyon · 2021Article
- Tiletamine/zolazepam and dexmedetomidine with tramadol provide effective general anesthesia in rats.Animal models and experimental medicine · 2021Article
- Combination treatment with VPA and MSCs‑TRAIL could increase anti‑tumor effects against intracranial glioma.Oncology reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The α2 adrenergic agonist xylazine produces a sedative effect and is typically combined with ketamine and used for anesthesia or chemical restraint of laboratory mice. Xylazine's sedative effect-and its undesirable side effects of bradycardia, hypotension, and poor tissue perfusion-can be reversed by administration of α2 antagonists, such as atipamezole or yohimbine. Although atipamezole and yohimbine dosing guidelines are available for mice, no controlled comparison has been performed to guide the lab animal community in the selection of one over the other. This study is a single-dose crossover comparison of these 2 antagonist drugs, given intraperitoneally at clinically recommended doses, to determine which results in more rapid recovery of mice from xylazine-ketamine anesthesia. Time to return of righting reflex was used as the primary outcome measure. Mice were anesthetized with xylazine (10 mg/kg IP) and ketamine (80 mg/kg IP), followed 15 min later by injection of an α2 antagonist or saline (control). Time to return of righting reflex differed significantly among groups, with mice recovering in an average of 10.3 min after administration of atipamezole (1 mg/kg IP) as compared with 21.3 min after yohimbine (1.5 mg/kg IP) and 38.2 min after saline. When rapid recovery of mice after xylazine-ketamine anesthesia is desirable, administration of an antagonist to reverse the effects of the xylazine is indicated. When injection of the antagonist by the technically simple intraperitoneal route is desirable, our data indicate that (at the doses evaluated) atipamezole is more effective than yohimbine.
Indexed as
Identifiers
28315642PMC5361038W2734918839What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.