Evidence map›Paper›PMID 28315028›Full record

ReviewDigestive diseases and sciences2017

Potential for Screening for Pancreatic Exocrine Insufficiency Using the Fecal Elastase-1 Test.

J Enrique Domínguez-Muñoz, Philip D Hardt, Markus M Lerch, Matthias J Löhr

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Digestive diseases and sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04690738 (Role of Pancreatic Exocrine Secretion in Weight Gain After Pancreas Transplantation), which is not on this map. Cited by 37 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 7 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04690738 suspendednot on this mapstarted 2020, after this paper: background citation

Role of Pancreatic Exocrine Secretion in Weight Gain After Pancreas Transplantation

TypeobservationalSponsorRush University Medical CenterRan2020 to 2030Enrolled50ConditionsExocrine Pancreatic Insufficiency, Weight GainArmsFecal Elastase Concentration
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 7 syntheses or guidelines pooled it, 108 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Guideline
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Review
  9. High Frequency of Pancreatic Exocrine Insufficiency Among Patients with Abdominal Pain, Bloating, and Malodorous Flatus: Hidden Pancreatic InsufficiencyThe Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2026
    Article
  10. Pancreatic exocrine insufficiency.EClinicalMedicine · 2026
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Diagnostic and therapeutic management of severe acute pancreatitis. Evidence based medicine (EBM) clinical practice guidelines.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

J Enrique Domínguez-MuñozDepartment of Gastroenterology and Hepatology, University Hospital of Santiago de Compostela, C/Choupana s/n, 15706, Santiago de Compostela, Spain. enriquedominguezmunoz@hotmail.com.
Philip D HardtMedical Department V, University Hospital, Giessen, Germany.
Markus M LerchDepartment of Medicine A, University Medicine Greifswald, Greifswald, Germany.
Matthias J LöhrDepartment of Digestive Diseases, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Karolinska University Hospital · SEUniversidade de Santiago de Compostela · ESUniversitätsklinikum Gießen und Marburg · DEUniversitätsmedizin Greifswald · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The early diagnosis of pancreatic exocrine insufficiency (PEI) is hindered because many of the functional diagnostic techniques used are expensive and require specialized facilities, which prevent their widespread availability. We have reviewed current evidence in order to compare the utility of these functional diagnostic techniques with the fecal elastase-1 (FE-1) test in the following three scenarios: screening for PEI in patients presenting with symptoms suggestive of pancreatic disease, such as abdominal pain or diarrhea; determining the presence of PEI in patients with an established diagnosis of pancreatic disease, such as chronic pancreatitis or cystic fibrosis; determining exocrine status in disorders not commonly tested for PEI, but which have a known association with this disorder. Evidence suggests the FE-1 test is reliable for the evaluation of pancreatic function in many pancreatic and non-pancreatic disorders. It is non-invasive, is less time-consuming, and is unaffected by pancreatic enzyme replacement therapy. Although it cannot be considered the gold-standard method for the functional diagnosis of PEI, the advantages of the FE-1 test make it a very appropriate test for screening patients who may be at risk of this disorder.

Indexed as

Cystic FibrosisExocrine Pancreatic InsufficiencyFecesHumansPancreatic ElastasePancreatitis, ChronicPancreatic ElastaseChronic pancreatitisDiabetes mellitusFecal elastase-1MalnutritionPancreatic exocrine insufficiency

Identifiers

PMID28315028
OpenAlexW2595748443

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.