Evidence map›Paper›PMID 28315010›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2017

Comparison of efficacy of meperidine and fentanyl in terms of pain management and quality of life in patients with cervical cancer receiving intracavitary brachytherapy: a double-blind, randomized controlled trial.

Saengrawee Thanthong, Sirikorn Rojthamarat, Wipra Worasawate, Phongthara Vichitvejpaisal, Danupon Nantajit, Nantakarn Ieumwananontachai

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02684942 (Comparison of Meperidine and Fentanyl on Pain Scale and Quality of Life in Cervical Cancer Patients Receiving Brachytherapy), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02684942 phase4completednot on this map

Comparison of Meperidine and Fentanyl on Pain Scale and Quality of Life in Cervical Cancer Patients Receiving Brachytherapy: A Double-blind, Randomized Controlled Trial

TypeinterventionalSponsorChulabhorn Cancer CenterRan2012 to 2014Enrolled40ConditionsPain, Quality of LifeArmsMeperidine, Fentanyl
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Effects of anesthetics on development of gynecological cancer.Frontiers in cell and developmental biology · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Saengrawee ThanthongDepartment of Radiation Oncology, Chulabhorn Hospital, Chulabhorn Royal Academy, 54 Kamphang Phet 6 Rd, Lak Si, Bangkok, 10210, Thailand. saengrawee81@gmail.com.ORCID 0000-0002-9350-3410
Sirikorn RojthamaratDepartment of Radiation Oncology, Chulabhorn Hospital, Chulabhorn Royal Academy, 54 Kamphang Phet 6 Rd, Lak Si, Bangkok, 10210, Thailand.
Wipra WorasawateDepartment of Anesthesiology, Chulabhorn Hospital, Chulabhorn Royal Academy, Bangkok, Thailand.
Phongthara VichitvejpaisalDepartment of Anesthesiology, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Danupon NantajitDepartment of Radiation Oncology, Chulabhorn Hospital, Chulabhorn Royal Academy, 54 Kamphang Phet 6 Rd, Lak Si, Bangkok, 10210, Thailand.
Nantakarn IeumwananontachaiDepartment of Radiation Oncology, Chulabhorn Hospital, Chulabhorn Royal Academy, 54 Kamphang Phet 6 Rd, Lak Si, Bangkok, 10210, Thailand.
Chulabhorn Hospital · THSiriraj Hospital · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was to compare the effectiveness of two sedative regimens, a benzodiazepine with either meperidine or fentanyl, in relieving pain in patients with cervical cancer undergoing intracavitary brachytherapy in terms of pain score and quality of life.

methodsForty unselected outpatients undergoing brachytherapy (160 fractions) were enrolled with informed consent and randomized to receive a benzodiazepine with either meperidine or fentanyl. The perceived pain score according to a standard 10-item numeric rating scale was collected every 15 min during the procedure, and the perceived quality of life was determined at the end of each procedure using the EuroQol five-dimension questionnaire. The patients and medical staff members directly involved with the procedure were blinded to the medication used.

resultsThe patients' pain levels were mild in both analgesic groups. Meperidine appeared to be slightly more effective than fentanyl, although the differences in the average pain score and quality of life were not statistically significant.

conclusionBoth meperidine and fentanyl in combination with benzodiazepine were effective in relieving pain and discomfort in patients undergoing brachytherapy.

trial registrationNCT02684942, ClinicalTrials.gov.

Indexed as

AdultAgedAged, 80 and overAnalgesics, OpioidBrachytherapyDouble-Blind MethodFemaleFentanylHumansMaleMeperidineMiddle AgedPain ManagementQuality of LifeUterine Cervical NeoplasmsYoung AdultAnalgesics, OpioidFentanylMeperidineBrachytherapyFentanylMeperidinePain managementQuality of life

Identifiers

PMID28315010
OpenAlexW2596552616

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.