Evidence map›Paper›PMID 28315005›Full record

ArticlePflugers Archiv : European journal of physiology2017

Effect of nitric oxide on renal autoregulation during hypothermia in the rat.

Lars Mikael Broman, Mattias Carlström, Örjan Källskog, Mats Wolgast

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Lars Mikael BromanECMO Centre Karolinska, Department of Pediatric Perioperative Medicine and Intensive Care, Karolinska University Hospital, 171 76, Stockholm, Sweden. lars.broman@karolinska.se.ORCID 0000-0003-4124-4581
Mattias CarlströmDepartment of Physiology and Pharmacology, Karolinska Institutet, 171 77, Stockholm, Sweden. mattias.carlstrom@ki.se.
Örjan KällskogDepartment of Medical Cell Biology, Section for Physiology, Uppsala University, 751 23, Uppsala, Sweden.
Mats WolgastDepartment of Medical Cell Biology, Section for Physiology, Uppsala University, 751 23, Uppsala, Sweden.
Uppsala University · SEKarolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypothermia-induced reduction of metabolic rate is accompanied by depression of both glomerular perfusion and filtration. The present study investigated whether these changes are linked to changes in renal autoregulation and nitric oxide (NO) signalling. During hypothermia, renal blood flow (RBF) and glomerular filtration rate (GFR) were reduced and urine production was increased, and this was linked with reduced plasma cGMP levels and increased renal vascular resistance. Although stimulation of NO production decreased vascular resistance, blood pressure and urine flow, intravenous infusion of the NO precursor L-arginine or the NO donor sodium nitroprusside did not alter RBF or GFR. In contrast, inhibition of NO synthesis by N

Indexed as

HomeostasisAnimalsGlomerular Filtration RateHypothermiaKidneyMaleNitric OxideRatsRats, Sprague-DawleyRenal CirculationVascular ResistanceNitric OxideAutoregulationGFRHypothermiaNitric oxideRenal blood flowVascular resistance

Identifiers

PMID28315005
PMCPMC5438424
OpenAlexW2596724310

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.