Evidence map›Paper›PMID 28314876›Full record

Trial reportHerz2018

Effect of remote ischemic postconditioning during thrombolysis in STEMI.

S Ghaffari, L Pourafkari, S Manzouri, N D Nader

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Herz, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

S GhaffariCardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
L PourafkariCardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
S ManzouriCardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
N D NaderDepartment of Anesthesiology, University at Buffalo, 77 Goodell Street, Suite #510, 14203, Buffalo, NY, USA. nnader@buffalo.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRemote ischemic postconditioning (RIPC) is suggested to protect the myocardium against ischemia in various settings. However, the effect of RIPC in patients with acute ST-elevation myocardial infarction (STEMI) who undergo thrombolysis has yet to be examined. PATIENTS AND

methodsIn this single-center, randomized controlled trial, we examined the effect of RIPC on the resolution of ST-segment elevation (STR) in response to thrombolysis. Patients in the RIPC group had three cycles of 5‑min cuff inflation followed by 5‑min deflation to the upper arm.

resultsThe study comprised 78 patients (15 women), of whom 41 were randomized to the RIPC group and 37 to the control group. STR occurred in 61% of the patients in the RIPC group, while it was detected only in 35% of controls (p = 0.026). Although STR was more common in the RIPC group, there was no difference in the extent of ΣCK-48 h between the two groups. Furthermore, the length of hospital stay and the frequency of adverse events were similar between the RIPC and control groups.

conclusionRIPC during thrombolytic therapy in STEMI was associated with a higher frequency of STR. However, it did not affect enzymatic infarct size or the frequency of adverse events. (Clinical trial registration number: IRCT2014011916229N2.).

Indexed as

Thrombolytic TherapyAgedElectrocardiographyFemaleHumansIschemic PostconditioningMaleMiddle AgedPrognosisST Elevation Myocardial InfarctionIschemiaMyocardiumReperfusionST-segment elevated myocardial infarction (STEMI)Thrombolytic therapy

Identifiers

PMID28314876

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.