Evidence map›Paper›PMID 28314800›Full record

ArticleJournal of the American Heart Association2017

Performance of the Atherosclerotic Cardiovascular Disease Pooled Cohort Risk Equations by Social Deprivation Status.

Lisandro D Colantonio, Joshua S Richman, April P Carson, Donald M Lloyd-Jones, George Howard, Luqin Deng, Virginia J Howard, Monika M Safford, Paul Muntner, David C Goff

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 5 pooled it
46.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 5 syntheses or guidelines pooled it, 88 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Lisandro D ColantonioDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, AL lcolantonio@uab.edu lisandro.colantonio@fulbrightmail.org.
Joshua S RichmanDepartment of Surgery, School of Medicine, University of Alabama at Birmingham, AL.
April P CarsonDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, AL.
Donald M Lloyd-JonesDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL.
George HowardDepartment of Biostatistics, School of Public Health, University of Alabama at Birmingham, AL.
Luqin DengDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, AL.
Virginia J HowardDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, AL.
Monika M SaffordDepartment of Medicine, Weill Cornell Medical College, New York, NY.
Paul MuntnerDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, AL.
David C GoffDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO.
Alabama Department of Public Health · USUniversity of Alabama at Birmingham · USNorthwestern University · USCornell University · USUniversity of Colorado Anschutz Medical Campus · US

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
Understanding Cohort Effects on Stroke, VCID, and Cognition After Major Epidemiologic TransitionsRF1NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2024 to 2024
$16.2M
REGARDS - MI StudyR01HL080477 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LEVITAN, EMILY B, SAFFORD, MONIKA M · 2006 to 2020
$11.6M
Understanding Cohort Effects on Stroke, VCID, and Cognition After Major Epidemiologic TransitionsR01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MARY CUSHMAN, VIRGINIA J. HOWARD · 2001 to 2026
$8.8M
Building Capacity for Cardiometabolic Outcomes ResearchK24HL111154 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SAFFORD, MONIKA M · 2012 to 2015
$556k
NHLBI NIH HHS K24 HL111154NHLBI NIH HHS R01 HL080477NIDDK NIH HHS P30 DK079626NINDS NIH HHS R01 NS041588NINDS NIH HHS RF1 NS041588NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

backgroundThe atherosclerosis cardiovascular disease (ASCVD) Pooled Cohort risk equations have shown different calibration across US populations with varied levels of social deprivation. METHODS AND

resultsWe analyzed the calibration and discrimination of the Pooled Cohort risk equations by social deprivation status among 9066 REGARDS (REasons for Geographic And Racial Differences in Stroke) study participants not taking statins for whom ASCVD risk may lead to statin initiation. Patients were aged 45 to 79 years, had no ASCVD or diabetes mellitus, and had a low-density lipoprotein cholesterol level 70 to 189 mg/dL. Social deprivation was defined using 3 indicators: annual household income <$25 000, less than a high school education, and living without a partner. At baseline in 2003-2007, 54.6%, 27.4%, and 18.0% of participants had 0, 1, and 2 or 3 indicators showing deprivation, respectively. From baseline through December 2012, 457 participants developed ASCVD (nonfatal/fatal stroke, myocardial infarction, or coronary heart disease death). Predicted and observed ASCVD incidence per 1000 person-years were 8.02 and 6.23 (95% CI, 5.31-7.31), respectively, among participants with 0 indicators of deprivation (Hosmer-Lemeshow

conclusionsThe Pooled Cohort risk equations have good calibration among individuals with social deprivation but overestimate ASCVD risk among those with less social deprivation.

Indexed as

Educational StatusSocial ClassAgedAtherosclerosisCardiovascular DiseasesCholesterol, LDLCohort StudiesCoronary DiseaseFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIncomeMaleMiddle AgedMyocardial InfarctionResidence CharacteristicsCholesterol, LDLHydroxymethylglutaryl-CoA Reductase Inhibitorscardiovascular diseaseprimary preventionrisk assessmentrisk factorsocioeconomic position

Identifiers

PMID28314800
PMCPMC5524046
OpenAlexW2595481514

What OpenQuestion holds

Texttitle and abstract
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.