SynthesisAnnals of the rheumatic diseases2017
Transethnic meta-analysis identifies
Abstract readMeta-AnalysisReview
In one paragraph
Synthesis in Annals of the rheumatic diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 4 pooled it
6.9field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 4 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Anti-RNA polymerase III antibodies in systemic sclerosis: prevalence and clinical associations from a systematic review and meta-analysis.Rheumatology (Oxford, England) · 2025Pooled it
- GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region.Nature communications · 2024Pooled it
- A cross-disease meta-GWAS identifies four new susceptibility loci shared between systemic sclerosis and Crohn's disease.Scientific reports · 2020Pooled it
- GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways.Nature communications · 2019Pooled it
- Gain of function NOTCH4 variants disrupt angiogenesis in systemic sclerosis.Annals of the rheumatic diseases · 2026Article
- Genetic and Genomic Analysis of Systemic Sclerosis: A Narrative Review of the Recent Advancement.JMA journal · 2026Review
- Genetic association ofFrontiers in genetics · 2026Article
- PRDM1-mediated epigenetic and transcriptional repression mechanisms: a key hub in immune differentiation, tumor progression, and inflammatory responses.Frontiers in immunology · 2026Review
- Comprehensive Profiling of Cytokines and Growth Factors: Pathogenic Roles and Clinical Applications in Autoimmune Diseases.International journal of molecular sciences · 2025Review
- Mechanistic insights into gasdermin-mediated pyroptosis.Nature reviews. Molecular cell biology · 2025Review
- Role of gasdermins in chronic kidney disease.Frontiers in immunology · 2025Review
- Biological and pharmacological roles of pyroptosis in pulmonary inflammation and fibrosis: recent advances and future directions.Cell communication and signaling : CCS · 2024Review
- Depletion of Gsdma1/2/3 alleviates PMA-induced epidermal hyperplasia by inhibiting the EGFR-Stat3/Akt pathway.Journal of molecular cell biology · 2024Article
- Gasdermin A (GSDMA) Tissue Expression, Serum and Urinary Concentrations with Clinicopathologic Outcome in Psoriasis.Dermatology practical & conceptual · 2024Article
- A dual-acting DNASE1/DNASE1L3 biologic prevents autoimmunity and death in genetic and induced lupus models.JCI insight · 2024Article
- Contribution of Telomere Length to Systemic Sclerosis Onset: A Mendelian Randomization Study.International journal of molecular sciences · 2023Article
- Pyroptosis and the cellular consequences of gasdermin pores.Seminars in immunology · 2023Review
- GSDMA3 deficiency reprograms cellular metabolism and modulates BCR signaling in murine B cells.iScience · 2023Article
- A Summary on the Genetics of Systemic Lupus Erythematosus, Rheumatoid Arthritis, Systemic Sclerosis, and Sjögren's Syndrome.Clinical reviews in allergy & immunology · 2023Review
- The gasdermin protein family: emerging roles in gastrointestinal health and disease.Nature reviews. Gastroenterology & hepatology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
54 authors at 20 institutions in 7 countries.
Chikashi TeraoDepartment of Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Takahisa KawaguchiDepartment of Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Philippe DieudeRheumatology Bichat Hospital, Paris 7 University, Paris, France.
John VargaNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Masataka KuwanaDivision of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Marie HudsonJewish General Hospital and Lady Davis Research Institute, Montreal, Quebec, Canada.
Yasushi KawaguchiInstitute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan.
Marco Matucci-CerinicDivision of Rheumatology AOUC, Department of Experimental and Clinical Medicine, Department of Medical & Geriatrics Medicine, University of Florence, Firenze, Italy.
Koichiro OhmuraDepartment of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Gabriela RiemekastenClinic for Rheumatology, University of Lübeck, Lübeck, Germany.
Aya KawasakiMolecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Paolo AiroRheumatology Unit, Spedali Civili, Brescia, Italy.
Tetsuya HoritaDivision of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Akira OkaThe Institute of Medical Science, Tokai University, Isehara, Japan.
Eric HachullaInternal Medicine Department, FHU Immune-Mediated Inflammatory Diseases and Targeted Therapies, Lille University, Lille, France.
Hajime YoshifujiDepartment of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Paola CaramaschiRheumatology Department, University of Verona, Azienda Ospedaliera Universitaria Integrata, Italy.
Nicolas HunzelmannDermatology Department, University of Koln, Koln, Germany.
Murray BaronJewish General Hospital and Lady Davis Research Institute, Montreal, Quebec, Canada.
Tatsuya AtsumiDivision of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Paul HassounDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Takeshi ToriiTorii Clinic, Kyoto, Japan.
Meiko TakahashiDepartment of Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Yasuharu TabaraDepartment of Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Masakazu ShimizuDepartment of Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Akiko TochimotoInstitute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan.
Naho AyuzawaDepartment of Rheumatology, National Hospital Organization, Utano National Hospital, Kyoto, Japan.
Hidetoshi YanagidaDepartment of Rheumatology, National Hospital Organization, Utano National Hospital, Kyoto, Japan.
Hiroshi FurukawaMolecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Shigeto TohmaClinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan.
Minoru HasegawaDivision of Medicine, Faculty of Medical Sciences, Department of Dermatology, University of Fukui, Fukui, Japan.
Manabu FujimotoDepartment of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Osamu IshikawaDepartment of Dermatology, Gunma University Graduate School of Medicine, Gunma, Japan.
Toshiyuki YamamotoDepartment of Dermatology, Fukushima Medical University, Fukushima, Japan.
Daisuke GotoDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Yoshihide AsanoDepartment of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Masatoshi JinninDepartment of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Hirahito EndoDivision of Rheumatology, Department of Internal Medicine, School of Medicine, Toho University, Tokyo, Japan.
Hiroki TakahashiDepartment of Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan.
Kazuhiko TakeharaDepartment of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan.
Shinichi SatoDepartment of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Hironobu IhnDepartment of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Soumya RaychaudhuriDivision of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Katherine LiaoDivision of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Peter GregersenRobert S. Boas Center for Genomics and Human Genetics, The Feinstein Institute for Medical Research, Manhasset, New York, USA.
Naoyuki TsuchiyaMolecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.ORCID http://orcid.org/0000-0002-6776-5580
Valeria RiccieriSapienza University of Rome, Rome, Italy.
Inga MelchersUniversity Medical Center, Freiburg, Germany.
Gabriele ValentiniDepartment of Clinical and Experimental Medicine, Rheumatology Section, Second University of Naples, Naples, Italy.
Anne CauvetINSERM U1016/UMR 8104, Cochin Institute, Paris Descartes University, Paris, France.
Maria MartinezINSERM U1220-IRSD-Batiment B Purpan Hospital Toulouse, Paris, France.
Tsuneyo MimoriDepartment of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Fumihiko MatsudaDepartment of Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Yannick AllanoreRheumatology A Department, INSERM U1016/UMR 8104, Cochin Institute, Paris Descartes University, Paris, France.
Kyoto University · JPUniversity of Tsukuba · JPBroad Institute · USDélégation Paris 5 · FRHokkaido University · JPJewish General Hospital · CAKumamoto University · JPNational Hospital Organization · JPThe University of Tokyo · JPTokyo Women's Medical University · JPAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITBrigham and Women's Hospital · USFeinstein Institute for Medical Research · USFukushima Medical University · JPGunma University · JPInserm · FRJA Toride Medical Center · JPJohns Hopkins University · USKanazawa University · JPKeio University · JP
Funding
Discovery and Functional Impact of Common and Rare Variants in RAR01AR063759 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Soumya Raychaudhuri · 2013 to 2026
$5.4MNIAMS NIH HHS R01 AR063759
Abstract
objectivesSystemic sclerosis (SSc) is an autoimmune disease characterised by skin and systemic fibrosis culminating in organ damage. Previous genetic studies including genome-wide association studies (GWAS) have identified 12 susceptibility loci satisfying genome-wide significance. Transethnic meta-analyses have successfully expanded the list of susceptibility genes and deepened biological insights for other autoimmune diseases.
methodsWe performed transethnic meta-analysis of GWAS in the Japanese and European populations, followed by a two-staged replication study comprising a total of 4436 cases and 14 751 controls. Associations between significant single nuclear polymorphisms (SNPs) and neighbouring genes were evaluated. Enrichment analysis of H3K4Me3, a representative histone mark for active promoter was conducted with an expanded list of SSc susceptibility genes.
resultsWe identified two significant SNP in two loci,
conclusions
Indexed as
Case-Control StudiesEuropeGasderminsGenetic Predisposition to DiseaseGenome-Wide Association StudyHLA AntigensHumansJapanNeoplasm ProteinsPolymorphism, Single NucleotidePositive Regulatory Domain I-Binding Factor 1Repressor ProteinsScleroderma, SystemicGasderminsGSDMA protein, humanHLA AntigensNeoplasm ProteinsPositive Regulatory Domain I-Binding Factor 1PRDM1 protein, humanRepressor ProteinsAutoimmune DiseasesGene PolymorphismSystemic Sclerosis
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