Evidence map›Paper›PMID 28314679›Full record

ArticleSchizophrenia research2018

An analysis of the rewarding and aversive associative properties of nicotine in the neonatal quinpirole model: Effects on glial cell line-derived neurotrophic factor (GDNF).

Russell W Brown, Seth L Kirby, Adam R Denton, John M Dose, Elizabeth D Cummins, Wesley Drew Gill, Katherine C Burgess

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Effects of positive mGlu5 modulation on DJournal of psychopharmacology (Oxford, England) · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Behavioral outputs of negative symptom domains of schizophrenia.Experimental and therapeutic medicine · 2021
    Article
  6. Review
  7. Effects of an adenosine AJournal of psychopharmacology (Oxford, England) · 2020
    Article
  8. Dopamine DThe Journal of pharmacology and experimental therapeutics · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Russell W BrownDepartment of Biomedical Sciences, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, United States. Electronic address: brown1@etsu.edu.
Seth L KirbyDepartment of Psychology, East Tennessee State University, Johnson City, TN 37614, United States.
Adam R DentonDepartment of Psychology, East Tennessee State University, Johnson City, TN 37614, United States.
John M DoseDepartment of Psychology, St. Norbert College, De Pere, WI 54115, United States.
Elizabeth D CumminsDepartment of Psychology, East Tennessee State University, Johnson City, TN 37614, United States.
Wesley Drew GillDepartment of Biomedical Sciences, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, United States.
Katherine C BurgessDepartment of Biomedical Sciences, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, United States.
East Tennessee State University · USSt. Norbert College · US

Funding

Nicotine and the roles of nicotinic receptors in a rodent model of schizophreniaR15DA034912 · NIDA · EAST TENNESSEE STATE UNIVERSITY · PI BROWN, RUSSELL WAYNE · 2013 to 2015
$450k
NIDA NIH HHS R15 DA034912
6 · The paper itself

Abstract

This study analyzed the associative properties of nicotine in a conditioned place preference (CPP) paradigm in adolescent rats neonatally treated with quinpirole (NQ) or saline (NS). NQ produces dopamine D

Indexed as

AssociationRewardAnimalsAnimals, NewbornAntipsychotic AgentsAvoidance LearningClozapineConditioning, PsychologicalGlial Cell Line-Derived Neurotrophic FactorHaloperidolMaleNicotineNicotinic AgonistsNucleus AccumbensQuinpiroleSpatial BehaviorAntipsychotic AgentsClozapineGdnf protein, ratGlial Cell Line-Derived Neurotrophic FactorHaloperidolNicotineNicotinic AgonistsQuinpiroleAdolescenceAntipsychoticsConditioned place preferenceDopamine D2 receptorNicotineSchizophrenia

Identifiers

PMID28314679
PMCPMC5599315
OpenAlexW2611332637

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.