Evidence map›Paper›PMID 28314591›Full record

ArticleImmunity2017

The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagasome Induction and the Metabolic Transition of Activated T Cells.

Michael I Whang, Rita M Tavares, Daniel I Benjamin, Michael G Kattah, Rommel Advincula, Daniel K Nomura, Jayanta Debnath, Barbara A Malynn, Averil Ma

Open access · bronzeAbstract read
In one paragraph

Article in Immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Mitochondrial dysfunction in Alzheimer's disease: Guiding the path to targeted therapies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Nutrients: Signal 4 in T cell immunity.The Journal of experimental medicine · 2024
    Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. NAC1 confines virus-specific memory formation of CD4Journal of medical virology · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Michael I WhangDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94143-0358, USA.
Rita M TavaresDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94143-0358, USA.
Daniel I BenjaminDepartments of Chemistry, Molecular and Cell Biology, and Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
Michael G KattahDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94143-0358, USA.
Rommel AdvinculaDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94143-0358, USA.
Daniel K NomuraDepartments of Chemistry, Molecular and Cell Biology, and Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
Jayanta DebnathDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143-0505, USA.
Barbara A MalynnDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94143-0358, USA.
Averil MaDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94143-0358, USA. Electronic address: averil.ma@ucsf.edu.
University of California, San Francisco · USUniversity of California, Berkeley · US

Funding

UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Holger Willenbring · 1986 to 2026
$30.7M
Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRUMMEL, MATTHEW F · 2003 to 2019
$21.8M
TRAINING PROGRAM IN DISGESTIVE DISEASES AND NUTRITIONT32DK007007 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AVERIL I MA · 1986 to 2026
$6.4M
A20 Mediated Regulation of Colitis and SpondyloarthritisR01DK095693 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MA, AVERIL I · 2012 to 2021
$3.1M
Ubiquitylation and the Regulation of Immune HomeostasisR56AI124457 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MA, AVERIL I · 2016 to 2016
$396k
NIAID NIH HHS R56 AI124457NIDDK NIH HHS P30 DK026743NIDDK NIH HHS P30 DK063720NIDDK NIH HHS R01 DK095693NIDDK NIH HHS T32 DK007007
6 · The paper itself

Abstract

During immune responses, naive T cells transition from small quiescent cells to rapidly cycling cells. We have found that T cells lacking TAX1BP1 exhibit delays in growth of cell size and cell cycling. TAX1BP1-deficient T cells exited G

Indexed as

AnimalsAutophagosomesAutophagyCell SeparationChromosomes, Artificial, BacterialIntracellular Signaling Peptides and ProteinsLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutNeoplasm ProteinsT-LymphocytesTOR Serine-Threonine KinasesIntracellular Signaling Peptides and ProteinsmTOR protein, mouseNeoplasm ProteinsTAX1BP1 protein, mouseTOR Serine-Threonine KinasesLC3selective autophagyubiquitin

Identifiers

PMID28314591
PMCPMC5400745
OpenAlexW2597989827

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.