Evidence map›Paper›PMID 28314564›Full record

ArticleReproductive toxicology (Elmsford, N.Y.)2017

Hydroxylated polychlorinated biphenyl metabolites (OH-PCBs), maternal smoking and size at birth.

Katrina Kezios, Yiwei Gu, Xinhua Liu, Piera Cirillo, Darcy Tarrant, Myrto Petreas, Jun-Soo Park, Barbara Cohn, Pam Factor-Litvak

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive toxicology (Elmsford, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Katrina KeziosDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Yiwei GuDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Xinhua LiuDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Piera CirilloChild Health and Development Studies, Public Health Institute, Berkeley, CA 94709, USA.
Darcy TarrantDepartment of Toxic Substances Control California Environmental Protection Agency, Berkeley, CA 94710, USA.
Myrto PetreasDepartment of Toxic Substances Control California Environmental Protection Agency, Berkeley, CA 94710, USA.
Jun-Soo ParkDepartment of Toxic Substances Control California Environmental Protection Agency, Berkeley, CA 94710, USA.
Barbara CohnChild Health and Development Studies, Public Health Institute, Berkeley, CA 94709, USA.
Pam Factor-LitvakDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA. Electronic address: prf1@cumc.columbia.edu.
Columbia University · USCalifornia Environmental Protection Agency · USBerkeley Public Health Division · US

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
Training Program in Environmental Life Course EpidemiologyT32ES023772 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FACTOR-LITVAK, PAM R, PERERA, FREDERICA P · 2015 to 2019
$1.3M
Prenatal organochlorines, thyroid, and developmentR01ES012460 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FACTOR-LITVAK, PAM R. · 2004 to 2006
$1.2M
Prenatal Organochlorine Metabolites, Thyroid Function and DevelopmentR01ES017024 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FACTOR-LITVAK, PAM R · 2009 to 2010
$1.0M
NIEHS NIH HHS P30 ES009089NIEHS NIH HHS R01 ES012460NIEHS NIH HHS R01 ES017024NIEHS NIH HHS T32 ES023772
6 · The paper itself

Abstract

In a sample of 442 births from the Child Health and Development Studies cohort, we examined associations between maternal prenatal exposure to hydroxylated polychlorinated biphenyl metabolites (OH-PCBs) and pregnancy outcomes, and whether associations were mediated by maternal thyroid hormone levels and/or modified by maternal smoking. Compared to nonsmokers, smokers had twice the mean concentration of 4-OH-CB107 (p<0.001) and lower levels of its parent compound, PCB118 (p=0.001). Among mothers who smoked, the birth weight of newborns with maternal concentrations of 4-OH-CB107 in the upper quartile was 316g lighter (95% confidence interval (CI) 566, 65) compared to those with maternal concentrations in the lowest quartile, after control for PCB118 and other potential confounders. This association was not observed for non-smoking mothers and was not mediated by maternal thyroid hormone levels. Maternal prenatal 4-OH-CB107 levels appear to be influenced by maternal smoking and contribute to lower birth weight among smokers.

Indexed as

Birth WeightAdolescentChildChild, PreschoolEndocrine DisruptorsEnvironmental PollutantsFemaleHumansHydroxylationMaleMaternal ExposureMothersPolychlorinated BiphenylsPregnancySmokingThyroid HormonesEndocrine DisruptorsEnvironmental PollutantsPolychlorinated BiphenylsThyroid HormonesBirth outcomesBirth weightGestational lengthHydroxylated PCB metabolitesMaternal smokingMaternal thyroid hormonePolychlorinated biphenyls

Identifiers

PMID28314564
PMCPMC5513775
OpenAlexW2606882147

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.