ArticleThyroid : official journal of the American Thyroid Association2017
Myocardial Induction of Type 3 Deiodinase in Dilated Cardiomyopathy.
Article in Thyroid : official journal of the American Thyroid Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- The thyroid-heart axis-hormone dynamics and outcomes in cardiogenic shock following myocardial infarction.Journal of the Intensive Care Society · 2026Article
- Low Thyroid Hormones Level Attenuates Mitochondrial Dysfunction and Right Ventricular Failure in Pulmonary Hypertensive Rats.Cardiovascular drugs and therapy · 2025Article
- Thyroid Hormones-An Underestimated Player in Dilated Cardiomyopathy?Journal of clinical medicine · 2021Review
- Paradigms of Dynamic Control of Thyroid Hormone Signaling.Endocrine reviews · 2019Review
- Hypothyroidism: Cardiovascular Endpoints of Thyroid Hormone Replacement.Frontiers in endocrinology · 2019Review
- Comparison of Therapeutic Triiodothyronine Versus Metoprolol in the Treatment of Myocardial Infarction in Rats.Thyroid : official journal of the American Thyroid Association · 2018Article
- Myocardium of patients with dilated cardiomyopathy presents altered expression of genes involved in thyroid hormone biosynthesis.PloS one · 2018Article
- Long-term prognostic value of combined free triiodothyronine and late gadolinium enhancement in nonischemic dilated cardiomyopathy.Clinical cardiology · 2018Observational
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe thyroid hormone-inactivating enzyme type 3 deiodinase (D3) is induced during hypertrophic and ischemic cardiomyopathy, leading to a state of local cardiac hypothyroidism. Whether D3 induction occurs in dilated cardiomyopathy is unknown.
methodsThis study characterized changes in cardiac D3 and thyroid hormone signaling in a transgenic model of progressive dilated cardiomyopathy (TG9 mice).
resultsCardiac D3 was dramatically induced 15-fold during the progression of dilated cardiomyopathy in TG9 mice. This D3 induction localized to cardiomyocytes and was associated with a decrease in myocardial thyroid hormone signaling.
conclusionsCardiac D3 is induced in a mouse model of dilated cardiomyopathy, indicating that D3 induction may be a general response to diverse forms of cardiomyopathy.
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