Evidence map›Paper›PMID 28314369›Full record

ArticleNanoscale research letters2017

Formulation and Drug Loading Features of Nano-Erythrocytes.

Xiaoting Dong, Yawei Niu, Yi Ding, Yuemin Wang, Jialan Zhao, Wei Leng, Linghao Qin

Abstract read
In one paragraph

Article in Nanoscale research letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Research Progress on Cell Membrane-Coated Biomimetic Delivery Systems.Frontiers in bioengineering and biotechnology · 2021
    Review
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaoting DongDepartment of Pharmaceutics, School of Pharmacy, Guangdong Pharmaceutical University, No. 280 Waihuandong Road, Guangzhou, 510006, China.
Yawei NiuDepartment of Pharmaceutics, School of Pharmacy, Guangdong Pharmaceutical University, No. 280 Waihuandong Road, Guangzhou, 510006, China.
Yi DingGuangzhou Institute for Drug Control, 23 Xizeng Road, Guangzhou, 510160, China.
Yuemin WangDepartment of Pharmaceutics, School of Pharmacy, Guangdong Pharmaceutical University, No. 280 Waihuandong Road, Guangzhou, 510006, China.
Jialan ZhaoDepartment of Pharmaceutics, School of Pharmacy, Guangdong Pharmaceutical University, No. 280 Waihuandong Road, Guangzhou, 510006, China.
Wei LengJacobson Pharma Group, 7 Dai Shun Street, Tai Po District, NT, Hong Kong.
Linghao QinDepartment of Pharmaceutics, School of Pharmacy, Guangdong Pharmaceutical University, No. 280 Waihuandong Road, Guangzhou, 510006, China. dor_qin@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nano erythrocyte ghosts have recently been used as drug carriers of water-soluble APIs due to inherit biological characteristics of good compatibility, low toxicity, and small side-effect. In this study, we developed a novel drug delivery system based on nano erythrocyte ghosts (STS-Nano-RBCs) to transport Sodium Tanshinone IIA sulfonate (STS) for intravenous use in rat. STS-Nano-RBCs were prepared by hypotonic lysis and by extrusion methods, and its biological properties were investigated compared with STS injection. The results revealed that STS-Nano-RBCs have narrow particle size distribution, good drug loading efficiency, and good stability within 21 days. Compared with STS injection, STS-Nano-RBCs extended the drug release time in vitro and in vivo with better repairing effect on oxidative stress-impaired endothelial cells. These results suggest that the nano erythrocyte ghosts system could be used to deliver STS.

Indexed as

Drug deliveryErythrocyte ghostsRepairing effectSTS

Identifiers

PMID28314369
PMCPMC5355415

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.