ArticleActa diabetologica latina
Nutrient induced insulin release from an insulinoma derived B-cell line.
Article in Acta diabetologica latina. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- Insulin releasing effects of mastoparan and amphiphilic substance P receptor antagonists on RINm5F insulinoma cells.Molecular and cellular biochemistry · 1992Article
- Increased glucose oxidation and contents of insulin and ATP in polyamine-depleted rat insulinoma cells (RINm5F).The Biochemical journal · 1991Article
- Cholinergic stimulation of insulin release from cloned B-cell lines HIT-T15 and RINm5F.Acta diabetologica latinaArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study describes the effect of nutrient secretagogues upon insulin release from an insulinoma derived B-cell line RINm5F. Glucose failed to stimulate insulin release, it did however increase the rate of glucose oxidation by some 16 fold. Glyceraldehyde stimulated insulin release in a concentration dependent manner, maximum stimulation occurring at 20 mmol/l. The response to glyceraldehyde was suppressed by calcium channel blockade and calmodulin inhibition. Insulin release was also stimulated by the amino acids leucine and arginine, maximum stimulation for both amino acids occurring at 15 mmol/l. The present study confirms the usefulness of this cell line as a model for the study of insulin secretion.
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