ArticleJournal of the American Geriatrics Society2017
Early Functional Limitations in Cognitively Normal Older Adults Predict Diagnostic Conversion to Mild Cognitive Impairment.
Article in Journal of the American Geriatrics Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 64 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Evaluation of a Multidimensional Behavioral Intervention for Those at Risk for Alzheimer's Dementia
A Nonrandomized Evaluation of a Multidimensional Behavioral Intervention for Those at Risk for Alzheimer's Dementia
Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Rehabilitation potential in older people living with frailty: a systematic mapping review.BMC geriatrics · 2021Pooled it
- Memory support training and lifestyle modifications to promote healthy aging in persons at risk for Alzheimer's disease: a digital application supported intervention (Brain Boosters).BMC geriatrics · 2023Trial
- Cognitively healthy life expectancy of older women and men in India.SSM - population health · 2026Article
- Item comprehension and content coverage of patient-reported outcome measures for long COVID: a qualitative study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Evaluating self- and informant-reported complaints as predictors of cognitive progression in subjective cognitive decline: A clinically-based evaluation.Journal of Alzheimer's disease : JAD · 2026Article
- Neural signatures of dual-task walking demands in individuals at risk of cognitive impairment.npj aging · 2026Article
- Neighborhood Disadvantage, Functional Difficulty, and Cognitive Decline among Older Mexican Americans.Journal of racial and ethnic health disparities · 2026Article
- Domain-specific changes in everyday cognition: Associations with diagnosis change and gray matter volume change.Neuropsychology · 2026Article
- Uncovering pathology, subjective cognitive complaints, and sex in early Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2026Article
- A Pilot Study of the Effect of Repeated Practice in Virtual Reality on Everyday Action Performance in Real Life.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025Article
- Neighborhood disadvantage and subjective cognitive function among older Black women.Psychology and aging · 2025Article
- Development of a physical performance summary score in middle age: Findings from the CARDIA Function study.American journal of epidemiology · 2025Article
- Alzheimer Disease Biomarkers and Subjective Cognitive Decline Among Hispanic and/or Latino Adults.JAMA network open · 2025Article
- Subjective cognitive complaints and future risk of dementia and cognitive impairment, which matters most.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2025Article
- Psychological, social, and health-related factors predict risk for financial exploitation.Communications psychology · 2025Article
- Study partner characteristics moderate the prediction of cognitive decline in aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Risk Factors for Poor Sleep Quality and Subjective Cognitive Decline in Older Adults Living in the United States During the COVID-19 Pandemic.Healthcare (Basel, Switzerland) · 2025Article
- Growth-associated protein 43 is associated with faster functional decline among amyloid-positive individuals with objectively defined subtle cognitive decline and mild cognitive impairment.Neuropsychology · 2025Article
- WMH Contributions to Cognitive Impairment: Rationale and Design of the Diverse VCID Study.Stroke · 2025Review
- The mobile everyday cognition scale (mECog): Development and pilot testing.The Clinical neuropsychologist · 2025Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectivesTo examine whether specific types of early functional limitations in cognitively normal older adults are associated with subsequent development of mild cognitive impairment (MCI), as well as the relative predictive value of self versus informant report in predicting diagnostic conversion to MCI.
designAs a part of a longitudinal study design, participants underwent baseline and annual multidisciplinary clinical evaluations, including a physical and neurological examination, imaging, laboratory work, and neuropsychological testing.
settingData used in this study were collected as part of longitudinal research at the University of California, Davis Alzheimer's Disease Center.
participantsIndividuals diagnosed as having normal cognition at study baseline who had an informant who could complete informant-based ratings and at least one follow-up visit (N = 324). MEASUREMENTS: Participants and informants each completed the Everyday Cognition Scale (ECog), an instrument designed to measure everyday function in six cognitively relevant domains.
resultsSelf- and informant-reported functional limitations on the ECog were associated with significantly greater risk of diagnostic conversion to MCI (informant: hazard ratio (HR) = 2.0, 95% confidence interval (CI) = 1.3-3.2, P = .002), with self-report having a slightly higher hazard (HR = 2.3, 95% CI = 1.4-3.6, P < .001). When controlling for baseline cognitive abilities, the effect remained significant for self- and informant-reported functional limitations.
conclusionDeficits in everyday memory and executive function domains were the strongest predictors of diagnostic conversion to MCI. Detection of early functional limitations may be clinically useful in assessing the future risk of developing cognitive impairment in cognitively normal older adults.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.