ArticleJournal of the American Geriatrics Society2017
Functional Status Modifies the Association of Blood Pressure with Death in Elders: Health and Retirement Study.
Article in Journal of the American Geriatrics Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Is the association between blood pressure and mortality in older adults different with frailty? A systematic review and meta-analysis.Age and ageing · 2019Pooled it
- Form and function of actin impacts actin health and aging.iScience · 2026Article
- Blood Pressure Control and Mortality Among US Veterans.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Form and function of actin impacts actin health and aging.bioRxiv : the preprint server for biology · 2025Article
- Brazilian Guidelines of Hypertension - 2025.Arquivos brasileiros de cardiologia · 2025Article
- Real-world safety of neurohormonal antagonist initiation among older adults following a heart failure hospitalization.ESC heart failure · 2023Observational
- Relationships of Cerebral Perfusion With Gait Speed Across Systolic Blood Pressure Levels and Age: A Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Feasibility of Precision Medicine in Hypertension Management-Scope and Technological Aspects.Journal of personalized medicine · 2022Article
- Management of Hypertension in the Elderly and Frail Patient.Drugs & aging · 2022Article
- Genetic variation ineLife · 2022Article
- Hypertension, the decline of activities of daily living (ADL) and frailty.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Review
- Impact of Frailty on the Relationship between Blood Pressure and Cardiovascular Diseases and Mortality in Young-Old Adults.Journal of personalized medicine · 2022Article
- How Low Should You Go in the Presence of Frailty?Hypertension (Dallas, Tex. : 1979) · 2022Article
- Systolic Blood Pressure and Mortality in Community-Dwelling Older Adults: The Role of Frailty.The journal of nutrition, health & aging · 2022Article
- Mortality in Elderly Patients Taking Furosemide: Prospective Cohorts Study.International journal of hypertension · 2022Article
- Brazilian Guidelines of Hypertension - 2020.Arquivos brasileiros de cardiologia · 2021Article
- Intensive vs Standard Blood Pressure Control in Adults 80 Years or Older: A Secondary Analysis of the Systolic Blood Pressure Intervention Trial.Journal of the American Geriatrics Society · 2020Article
- Heterogeneous Exposure Associations in Observational Cohort Studies: The Example of Blood Pressure in Older Adults.American journal of epidemiology · 2020Article
- Blood pressure management in older adults: A multiple-choice question?Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- The role of functional status on the relationship between blood pressure and cognitive decline: the Cardiovascular Health Study.Journal of hypertension · 2019Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo examine whether grip strength, gait speed, and the combination of the two physical functioning measures modified the association of systolic BP (SBP) and diastolic BP (DBP) with mortality.
designNationally representative cohort study.
settingHealth and Retirement Study.
participants7,492 U.S. adults aged ≥65 years. MEASUREMENTS: Grip strength was measured by a hand dynamometer and classified as normal (≥16 kg for female; ≥26 kg for male) and weak. Gait speed was assessed over a 98.5-inch walk and classified as non-slow (≥0.60 m/s for female; ≥0.52 m/s for male) and slow.
resultsOver an average follow-up time of 6.0 years, 1,870 (25.0%) participants died. After adjustment for socio-demographic, behavioral, and clinical measures, elevated SBP (≥150 mmHg) and DBP (≥90 mmHg) was associated with a 24% (95% CI, 7-43%) and 25% (95% CI, 5-49%) higher mortality among participants with normal grip strength. In contrast, elevated SBP and DBP was associated with a 6% (95% CI, 31 to -27%) and a 16% (95% CI, 46 to -26%) lower mortality among those with weak grip strength (P-values of interactions: both=.07). The inverse relations between BP with death were most pronounced among slow walkers with weak grip strength. The HRs of elevated SBP and DBP for death was 0.85 (95% CI, 0.56-1.29) and 0.53 (95% CI, 0.30-0.96), respectively, and was substantially different from non-slow walkers with normal grip strength (HR = 1.24 and 1.15, respectively; P-values of interactions: both <.001). Therefore, associations of BP with death varied modestly by gait speed.
conclusionGrip strength modified the association of BP with death. Combination of grip strength and gait speed has incremental value for modifying the association of BP with death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.