ArticleJournal of the American Geriatrics Society2017
Exclusion of Elderly People from Randomized Clinical Trials of Drugs for Ischemic Heart Disease.
Article in Journal of the American Geriatrics Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Age-based exclusion is common and multifactorial in spinal RCTs: a systematic review and quantitative analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023Pooled it
- Impact of differences in acute respiratory distress syndrome randomised controlled trial inclusion and exclusion criteria: systematic review and meta-analysis.British journal of anaesthesia · 2021Pooled it
- Maximising inclusivity in care home research: Lessons learned from the AFRI-c randomised controlled trial.The Journal of frailty & aging · 2025Trial
- An analysis of DPV and DIVE registry patients with chronic kidney disease according to the finerenone phase III clinical trial selection criteria.Cardiovascular diabetology · 2023Trial
- Exclusion by design: enrollment criteria limit older adult participation in SARS-CoV-2 vaccine clinical trials.Journal of clinical epidemiology · 2026Article
- Demographics and clinical outcomes of patients with acute heart failure : The Acute Heart Failure Registry from the Clinic Ottakring (AHF-COR Registry).Wiener klinische Wochenschrift · 2026Article
- Hospitalizations for Major Cardiovascular Events in Patients Aged 75 Years or Older with Chronic Coronary Syndrome for the Whole Life Span.Journal of clinical medicine · 2025Article
- Botulinum Toxin Underuse in Older Stroke Survivors with Spasticity: A Nationwide Population-Based Cohort Study.Neuroepidemiology · 2025Article
- Acute Coronary Syndrome Management in Older Patients: A Dual-Center Retrospective Cohort Study.Medicina (Kaunas, Lithuania) · 2025Article
- Associations of high-risk drug patterns with mortality among community-dwelling older adults: A 23-year prospective cohort study.PloS one · 2025Article
- Toolkit for adapting community engagement studios to effectively engage older adults in research.Journal of clinical and translational science · 2025Article
- Acute Coronary Syndrome in Elderly Patients: How to Tackle Them?Journal of clinical medicine · 2024Review
- Exclusion of older patients from randomized clinical trials in Parkinson's disease.GeroScience · 2024Article
- The global burden of ischemic heart disease attributed to high fasting plasma glucose: Data from 1990 to 2019.Heliyon · 2024Article
- The current status of clinical trials on cancer and age disparities among the most common cancer trial participants.BMC cancer · 2024Article
- Optimal anti-platelet therapy for older patients with acute coronary syndrome: a network meta-analysis of randomized trials comprising 59,284 older patients.Journal of thrombosis and thrombolysis · 2024Article
- Current and future landscape of cardiogeriatrics.Future cardiology · 2024Article
- Asia-Pacific Investigators and Asian Enrollment in Cardiometabolic Trials: Insights From Publications Between 2011 and 2020.JACC. Asia · 2023Article
- Impact of Advanced Age on the Incidence of Major Adverse Cardiovascular Events in Patients with Type 2 Diabetes Mellitus and Stable Coronary Artery Disease in a Real-World Setting in Spain.Journal of clinical medicine · 2023Article
- Limitations of randomised controlled trials as evidence of drug safety.Australian prescriber · 2023Article
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Authors and funding
5 authors.
Funding
Abstract
objectivesTo measure exclusion of elderly adults from randomized trials studying drug interventions for ischemic heart disease (IHD) and describe the characteristics of these trials.
designCross-sectional analysis.
settingInterventional clinical trials studying a drug intervention for IHD that started in 2006 and after were identified in ClinicalTrials.gov. Data were extracted on study features, including age-based inclusion criteria. Data on participants and their age distribution were collected from trial publications, investigator inquiry, and result data in ClinicalTrials.gov.
participantsIndividuals aged 65 and older. MEASUREMENTS: Proportion of trials excluding individuals based on age, mean age of trial participants, and proportion of enrolled participants aged 65 and older and 75 and older.
resultsOf 839 identified trials, 446 (53%) explicitly excluded elderly adults. The most-frequent upper age limits were 80 (n = 164) and 75 (n = 114), with a median upper age limit of 80 (interquartile range 75-80). Trials with upper age limit exclusions tended to be smaller (median number of participants 100 vs 201, P < .001) and were more likely to be funded primarily by nonindustry sources (78.3% vs 70.0%, P = .006). The overall mean age of trial participants was 62.7 (mean maximum age 74). The estimated proportion of participants aged 65 and older was 42.5% and the estimated proportion aged 75 and older was 12.3%.
conclusionDespite the high burden of IHD in elderly adults, the majority of drug trials do not enroll participants reflective of age-related prevalence of the disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.