ArticleJournal of Alzheimer's disease : JAD2017
The Progression of Alzheimer's Disease: Are Fast Decliners Really Fast? A Four-Year Follow-Up.
Article in Journal of Alzheimer's disease : JAD, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Dementia-specific adaptations to physical performance tests of balance, mobility, and lower limb strength and function: a reliability study in people with dementia.BMC geriatrics · 2025Article
- AutoRADP: An Interpretable Deep Learning Framework to Predict Rapid Progression for Alzheimer's Disease and Related Dementias Using Electronic Health Records.medRxiv : the preprint server for health sciences · 2025Article
- Fast Declining Prediction in Alzheimer's Disease from Early Clinical Assessment.Current neuropharmacology · 2025Observational
- Temporal atrophy together with verbal encoding impairment is highly predictive for cognitive decline in typical Alzheimer's dementia - a retrospective follow-up study.Frontiers in psychiatry · 2024Article
- Could tau-PET imaging contribute to a better understanding of the different patterns of clinical progression in Alzheimer's disease? A 2-year longitudinal study.Alzheimer's research & therapy · 2023Article
- Subjective cognitive decline, mild cognitive impairment, and dementia - syndromic approach: recommendations of the Scientific Department of Cognitive Neurology and Aging of the Brazilian Academy of Neurology.Dementia & neuropsychologia · 2022Article
- Long-term use of pharmacological treatment in Alzheimer's disease: a retrospective cohort study in real-world clinical practice.European journal of clinical pharmacology · 2022Article
- Potential Applications of Artificial Intelligence in Clinical Trials for Alzheimer's Disease.Life (Basel, Switzerland) · 2022Review
- AD Course Map charts Alzheimer's disease progression.Scientific reports · 2021Article
- Identification of a Cascade of Changes in Activities of Daily Living Preceding Short-Term Clinical Deterioration in Mild Alzheimer's Disease Dementia via Lead-Lag Analysis.Journal of Alzheimer's disease : JAD · 2020Article
- ABC Dementia Scale Classifies Alzheimer's Disease Patients into Subgroups Characterized by Activities of Daily Living, Behavioral and Psychological Symptoms of Dementia, and Cognitive Function.Journal of Alzheimer's disease : JAD · 2020Article
- A multicenter cohort study to investigate the factors associated with functional autonomy change in patients with cognitive complaint or neurocognitive disorders: the MEMORA study protocol.BMC geriatrics · 2019Article
- Understanding and predicting the longitudinal course of dementia.Current opinion in psychiatry · 2019Review
- Rapidly Progressive Alzheimer's Disease in Two Distinct Autopsy Cohorts.Journal of Alzheimer's disease : JAD · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe rate of cognitive and functional decline in Alzheimer's disease (AD) changes across individuals.
objectivesOur purpose was to assess whether the concept of "fast decline" really fits its definition and whether cognitive and functional variables at onset can predict the progression of AD.
methods324 AD patients were included. We retrospectively examined their Mini-Mental State Examination (MMSE) total score and sub-items, Activities of Daily Living (ADL), and Instrumental Activities of Daily Living (IADL) at baseline and every six months for a 4-year follow-up. Patients were divided into "fast decliners" (n = 62), defined by a loss ≥5 points on the MMSE score within the first year from the baseline; "intermediate decliners" (n = 37), by a loss ≥5 points after the first year and before the 18th month; or "slow decliners" (n = 225), composed of the remaining patients.
resultsAt baseline, the groups did not differ on demographic, clinical, and cognitive variables. The decline at the end of the 4-year follow-up period seems to be similar among the different decline clusters. Predictors of disease progression have not been identified; only the MMSE total score at 12 months <14/30 was indicative of a poor prognosis.
conclusionsEven with the limitation due to the small sample size, the lack of differences in the disease progression in time in the different clusters suggest the inconsistency of the so-called "fast decliners". This study was unable to show any significant difference among clusters of AD progression within a 4-year time interval. Further studies should better clarify whether a more consistent distinction exists between slow and fast decliners.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.