Evidence map›Paper›PMID 28304298›Full record

ArticleJournal of Alzheimer's disease : JAD2017

Exercise Training and Functional Connectivity Changes in Mild Cognitive Impairment and Healthy Elders.

Theresa J Chirles, Katherine Reiter, Lauren R Weiss, Alfonso J Alfini, Kristy A Nielson, J Carson Smith

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 12 pooled it
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 12 syntheses or guidelines pooled it, 161 citations in OpenAlex.

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  12. Exercise for Cognitive Symptoms in Depression: A Systematic Review of Interventional Studies.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2018
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49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Theresa J ChirlesUniversity of Maryland, College Park, MD, USA.
Katherine ReiterMarquette University, Milwaukee, WI, USA.
Lauren R WeissUniversity of Maryland, College Park, MD, USA.
Alfonso J AlfiniUniversity of Maryland, College Park, MD, USA.
Kristy A NielsonMarquette University, Milwaukee, WI, USA.
J Carson SmithUniversity of Maryland, College Park, MD, USA.
University of Maryland, College Park · USMarquette University · US

Funding

Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI Arnold Bakker · 2020 to 2026
$29.3M
Clincal and Translational Science AwardUL1TR000055 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI SHAKER, REZA NONE · 2012 to 2015
$11.3M
Research Training in Age-Related Cognitive DisordersT32AG027668 · NIA · JOHNS HOPKINS UNIVERSITY · PI MARILYN S. ALBERT · 2007 to 2026
$6.3M
Clinical and Translational Science AwardKL2TR000056 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI SHAKER, REZA NONE · 2012 to 2015
$609k
NCATS NIH HHS KL2 TR000056NCATS NIH HHS UL1 TR000055NIA NIH HHS P30 AG066507NIA NIH HHS T32 AG027668
6 · The paper itself

Abstract

backgroundEffective interventions are needed to improve brain function in mild cognitive impairment (MCI), an early stage of Alzheimer's disease (AD). The posterior cingulate cortex (PCC)/precuneus is a hub of the default mode network (DMN) and is preferentially vulnerable to disruption of functional connectivity in MCI and AD.

objectiveWe investigated whether 12 weeks of aerobic exercise could enhance functional connectivity of the PCC/precuneus in MCI and healthy elders.

methodsSixteen MCI and 16 healthy elders (age range = 60-88) engaged in a supervised 12-week walking exercise intervention. Functional MRI was acquired at rest; the PCC/precuneus was used as a seed for correlated brain activity maps.

resultsA linear mixed effects model revealed a significant interaction in the right parietal lobe: the MCI group showed increased connectivity while the healthy elders showed decreased connectivity. In addition, both groups showed increased connectivity with the left postcentral gyrus. Comparing pre to post intervention changes within each group, the MCI group showed increased connectivity in 10 regions spanning frontal, parietal, temporal and insular lobes, and the cerebellum. Healthy elders did not demonstrate any significant connectivity changes.

conclusionThe observed results show increased functional connectivity of the PCC/precuneus in individuals with MCI after 12 weeks of moderate intensity walking exercise training. The protective effects of exercise training on cognition may be realized through the enhancement of neural recruitment mechanisms, which may possibly increase cognitive reserve. Whether these effects of exercise training may delay further cognitive decline in patients diagnosed with MCI remains to be demonstrated.

Indexed as

ExerciseAgedAged, 80 and overCognitive DysfunctionExercise TestFemaleGyrus CinguliHumansImage Processing, Computer-AssistedLinear ModelsMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsOxygenPsychiatric Status Rating ScalesOxygenAgingAlzheimer’s diseasecognitive disordersconnectivitydefault mode networkexercise interventionneural plasticityposterior cingulateprecuneusresting state functional MRI

Identifiers

PMID28304298
PMCPMC6472271
OpenAlexW2596970083

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.