Evidence map›Paper›PMID 28304254›Full record

ArticleComparative medicine2016

Clinical

Elana R Rybak, Steve Shipley, Ivan Tatarov, Tianshu Zhang, Wenji Sun, Gheorghe Braileanu, Lars Burdorf, Evelyn Sievert, Agnes M Azimzadeh, Louis J DeTolla and 1 more

Open access · greenAbstract readCase Reports
PubMed Full text at PMC
In one paragraph

Article in Comparative medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Reproductive Outcomes in Rhesus Macaques (Comparative medicine · 2020
    Article
  3. [Experimental research on Arginine-gingipain A gene vaccine from Porphyromonas gingivalis that prevents peri-implantitis in Beagle dogs].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Elana R RybakDepartment of Surgery First Equine, Dover, Delaware, Banfield Pet Hospital, Laurel, Maryland.
Steve ShipleyDepartment of Surgery and Comparative Medicine Program and Veterinary Resources, University of Maryland School of Medicine, Baltimore, Maryland; Division of Laboratory Animal Medicine, University of North Carolina, Chapel Hill, North Carolina; These authors contributed equally to the study.
Ivan TatarovDepartment of Surgery and Comparative Medicine Program and Veterinary Resources, University of Maryland School of Medicine, Baltimore, Maryland;, Email: itatarov@smail.umaryland.edu.
Tianshu ZhangDepartment of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Wenji SunDepartment of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Gheorghe BraileanuDepartment of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Lars BurdorfDepartment of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Evelyn SievertDepartment of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Agnes M AzimzadehDepartment of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Louis J DeTollaComparative Medicine Program and Veterinary Resources, University of Maryland School of Medicine, Baltimore, Maryland.
Richard N PiersonDepartment of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
University of Maryland, Baltimore · US

Funding

Immunomodulation for Heart Allograft ToleranceU01AI066719 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PIERSON, RICHARD N · 2005 to 2016
$8.5M
NIAID NIH HHS U01 AI066719
6 · The paper itself

Abstract

A cynomolgus macaque received a heterotopic cardiac allograft as part of a transplant study, with monoclonal antibodies targeted to specific immune costimulation molecules (CD154, CD28) but no traditional immunosuppressive therapy after surgery. Clinical anemia was detected on postoperative day (POD) 35 and had worsened (Hgb, 2.3 g/dL; Hct = 7.3%) by POD 47, despite type-matched whole-blood transfusions. After a total of 4 blood transfusions, hematologic parameters were improved (Hgb, 5.9 g/dL; Hct, 18.7%). On POD 50, a peripheral blood smear revealed trypomastigotes, and qualitative RT-PCR of whole blood identified the organism as Trypanosoma cruzi. Although clinically stable initially, the macaque soon developed sufficient weight loss to necessitate euthanasia on POD 64. The final diagnosis was clinical anemia due to T. cruzi infection. This study represents the first reported case of Chagas disease after heart transplant in a NHP.

Indexed as

Macaca fascicularisAnemiaAnimalsBlood TransfusionChagas DiseaseEosinophilsFemaleHeartHeart TransplantationImmunosuppressive AgentsMaleMonkey DiseasesTrypanosoma cruziImmunosuppressive Agents

Identifiers

PMID28304254
PMCPMC5157966
OpenAlexW2991509590

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.