ArticleThe Laryngoscope2017
Influence of human papillomavirus on the clinical presentation of oropharyngeal carcinoma in the United States.
Article in The Laryngoscope, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- USA dental health providers' role in HPV vaccine communication and HPV-OPC protection: a systematic review.Human vaccines & immunotherapeutics · 2019Pooled it
- Incidence and distribution of contralateral lymph node metastasis associated with human papillomavirus-related oropharyngeal squamous cell carcinoma.The Journal of laryngology and otology · 2024Article
- Head and Neck Squamous Cell Carcinoma of Unknown Primary: A Diagnostic Work-Up.The oncologist · 2024Article
- The radiological features of HPV-positive vs HPV-negative OPSCC at a South African hospital.SA journal of radiology · 2024Article
- Implications of oral dysbiosis and HPV infection in head and neck cancer: from molecular and cellular mechanisms to early diagnosis and therapy.Frontiers in oncology · 2023Review
- Prevalence of Transcriptionally Active HPV Infection in Tumor-Free Oropharyngeal Tissue of OPSCC-Patients.Frontiers in oncology · 2022Article
- Human Papillomavirus-Associated Head and Neck Cancers. Where are We Now? A Systematic Review.Cancer management and research · 2022Review
- Heterotypic neutrophil-in-tumor structure: A novel pathological feature first discovered in the tissues of OPSCC.Frontiers in oncology · 2022Article
- [Functional evaluation of anterolateral thigh flap and forearm flap for repairing defects after oropharyngeal cancer].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021Article
- Article
- Risk factors for human papillomavirus-positive nonoropharyngeal squamous cell carcinoma.Head & neck · 2020Article
- Outcomes of HPV-Associated Squamous Cell Carcinoma of the Head and Neck: Impact of Race and Socioeconomic Status.Journal of the National Comprehensive Cancer Network : JNCCN · 2020Article
- Evaluating the Effectiveness of Human Papillomavirus Educational Intervention among Oral Health Professionals.Journal of cancer education : the official journal of the American Association for Cancer Education · 2019Article
- Societal cost of oropharyngeal cancer by human papillomavirus status, cancer stage, and subsite.PloS one · 2019Article
- Correlation between Human Papillomavirus Status and Quantitative MR Imaging Parameters including Diffusion-Weighted Imaging and Texture Features in Oropharyngeal Carcinoma.AJNR. American journal of neuroradiology · 2018Article
- Prognostic factors for human papillomavirus-positive and negative oropharyngeal carcinomas.The Laryngoscope · 2018Article
- [HPV - A different view on Head and Neck Cancer].Laryngo- rhino- otologie · 2018Review
- How Does Smoking Change the Clinicopathological Characteristics of Human Papillomavirus-Positive Oropharyngeal Squamous Cell Carcinoma? One Medical Center Experience.Clinical medicine insights. Ear, nose and throat · 2018Article
- Clinical impact of human papillomavirus in laryngeal squamous cell carcinoma: a retrospective study.PeerJ · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectiveMuch of what is known about the significance of human papillomavirus (HPV) in oropharyngeal squamous cell carcinoma is derived from single-institution retrospective studies, post hoc analyses of tissue specimens from clinical trials, and tissue bank studies with a small sample size. The objective of this study is to investigate the impact of HPV on the frequency and clinical presentation of oropharyngeal carcinoma in a large, national sample with information from patients who underwent HPV testing. STUDY
designRetrospective, cross-sectional study.
methodsWe identified a comprehensive national sample of 8,359 patients with oropharyngeal carcinoma and known HPV status diagnosed between 2010 and 2011 within the National Cancer Database. Multivariable logistic regression was used to assess correlates of patient and tumor characteristics on HPV status.
resultsAmong patients with oropharyngeal carcinoma, the frequency of HPV-related squamous cell carcinoma in the United States was 65.4%. HPV-related oropharyngeal carcinoma was associated with younger age, male sex, and white race (P < 0.001). Advanced primary tumor stage was associated with HPV-negative disease (P < 0.001), whereas increasing nodal burden was associated with HPV-positive disease (P < 0.001). Despite less-advanced nodal disease, HPV-negative tumors were associated with a higher likelihood of metastasis at presentation (P < 0.001).
conclusionHPV now accounts for the majority of newly diagnosed oropharyngeal carcinoma in the United States and is associated with a distinct clinical profile, supporting efforts to re-evaluate the staging and treatment paradigm for HPV-associated oropharyngeal cancer. LEVEL OF EVIDENCE: 4. Laryngoscope, 127:2270-2278, 2017.
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