Evidence map›Paper›PMID 28304078›Full record

ReviewFEBS letters2017

Moving messages in the developing brain-emerging roles for mRNA transport and local translation in neural stem cells.

Louis-Jan Pilaz, Debra L Silver

Open access · bronzeAbstract readReview
In one paragraph

Review in FEBS letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. mRNA Transport and Local Translation in Glia.Trends in cell biology · 2021
    Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Neural Progenitor Cell Polarity and Cortical Development.Frontiers in cellular neuroscience · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Louis-Jan PilazDepartment of Molecular Genetics and Microbiology, Regeneration Next, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0002-9035-1327
Debra L SilverDepartment of Molecular Genetics and Microbiology, Regeneration Next, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0001-9189-844X
Duke Medical Center · USDuke University · US

Funding

Training Program in Developmental & Stem Cell BiologyT32HD040372 · NICHD · DUKE UNIVERSITY · PI Terry H Lechler · 2001 to 2026
$8.9M
Mechanisms of neural progenitor division in the developing brainR01NS083897 · NINDS · DUKE UNIVERSITY · PI SILVER, DEBRA · 2013 to 2023
$3.4M
Analysis of the Exon Junction Complex in Neural Development and MicrocephalyR00NS064197 · NINDS · DUKE UNIVERSITY · PI SILVER, DEBRA · 2011 to 2013
$720k
NICHD NIH HHS T32 HD040372NINDS NIH HHS R00 NS064197NINDS NIH HHS R01 NS083897
6 · The paper itself

Abstract

The mammalian cerebral cortex is a complex brain structure integral to our higher cognition. During embryonic cortical development, radial glial progenitors (RGCs) produce neurons and serve as physical structures for migrating neurons. Recent discoveries highlight new roles for RNA localization and local translation in RGCs, both at the cell body and at distal structures called basal endfeet. By implementing technologies from the field of RNA research to brain development, investigators can manipulate RNA-binding proteins as well as visualize single-molecule RNAs, live movement of mRNAs and their binding proteins, and translation. Going forward, these studies establish a framework for investigating how post-transcriptional RNA regulation helps shape RGC function and triggers neurodevelopmental diseases.

Indexed as

AnimalsBrainEpendymoglial CellsHumansModels, BiologicalNeural Stem CellsRNA-Binding ProteinsRNA, MessengerRNA TransportRNA-Binding ProteinsRNA, MessengerneurogenesisRNA localizationtranslation

Identifiers

PMID28304078
PMCPMC5497576
OpenAlexW2596399613

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.