ArticleScientific reports2017
Altered microstructure rather than morphology in the corpus callosum after lower limb amputation.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Brain-Machine Interface Induced Morpho-Functional Remodeling of the Neural Motor System in Severe Chronic Stroke.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Trial
- Functional-Structural Plasticity Associated With the Duration of Sports Participation in Lower Limb Amputees: A Multimodal Neuroimaging Study.Neural plasticity · 2026Article
- Brain Connectivity, Neural Networks, and Resilience in Aging and Neurodegeneration.The American journal of pathology · 2025Review
- Changes in hemispheric dominance following targeted muscle reinnervation: a case study.Frontiers in human neuroscience · 2025Article
- Cerebellar functional connectivity alteration in individuals with lower limb amputation.PloS one · 2025Article
- Cortical Reorganization after Limb Loss: Bridging the Gap between Basic Science and Clinical Recovery.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Case report: Symmetrical and increased lateral sway-based walking training for patients with corpus callosum infarction: a case series.Frontiers in neurology · 2024Article
- Spectral-based thickness profiling of the corpus callosum enhances anomaly detection in fetal alcohol spectrum disorders.Frontiers in neuroscience · 2023Article
- Motor Imagery-Related Changes of Neural Oscillation in Unilateral Lower Limb Amputation.Frontiers in neuroscience · 2022Article
- Interference of unilateral lower limb amputation on motor imagery rhythm and remodeling of sensorimotor areas.Frontiers in human neuroscience · 2022Article
- Deficit of Inhibition as a Marker of Neuroplasticity (DEFINE Study) in Rehabilitation: A Longitudinal Cohort Study Protocol.Frontiers in neurology · 2021Article
- Increased white matter diffusivity associated with phantom limb pain.The Korean journal of pain · 2019Article
- Microstructural integrity of corticospinal and medial lemniscus tracts: insights from diffusion tensor tractography of right-hand amputees.Journal of neurophysiology · 2019Article
- Functional plasticity of the ipsilateral primary sensorimotor cortex in an elite long jumper with below-knee amputation.NeuroImage. Clinical · 2019Article
- Brain Functional Connectivity Plasticity Within and Beyond the Sensorimotor Network in Lower-Limb Amputees.Frontiers in human neuroscience · 2018Article
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8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The corpus callosum (CC) has been implicated in the reorganization of the brain following amputation. However, it is unclear which regions of the CC are involved in this process. In this study, we explored the morphometric and microstructural changes in CC subregions in patients with unilateral lower limb amputation. Thirty-eight patients and 38 age- and gender-matched normal controls were included. The CC was divided into five regions, and the area, thickness and diffusion parameters of each region were investigated. While morphometric analysis showed no significant differences between the two groups, amputees showed significant higher values in axial diffusivity, radial diffusivity and mean diffusivity in region II of the CC, which connects the bilateral premotor and supplementary motor areas. In contrast, the mean fractional anisotropy value of the fibers generated by these cortical areas, as measured by tractography, was significantly smaller in amputees. These results demonstrate that the interhemispheric pathways contributing to motor coordination and imagery are reorganized in lower limb amputees.
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