Evidence map›Paper›PMID 28303931›Full record

ArticleScientific reports2017

The development of novel LTA

Caroline M Low, Samia Akthar, Dhiren F Patel, Stephan Löser, Chi-Tung Wong, Patricia L Jackson, J Edwin Blalock, Stephen A Hare, Clare M Lloyd, Robert J Snelgrove

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Using Omics to Identify Novel Therapeutic Targets in Heart Failure.Circulation. Genomic and precision medicine · 2024
    Review
  8. Characterization ofJournal of medical microbiology · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Abnormal pro-gly-pro pathway and airway neutrophilia in pediatric cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2020
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Caroline M LowComputational Drug Design Consultant, Dulwich, London SE21 8LS, United Kingdom.
Samia AktharInflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, United Kingdom.
Dhiren F PatelInflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, United Kingdom.
Stephan LöserInflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, United Kingdom.
Chi-Tung WongDepartment of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom.
Patricia L JacksonDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
J Edwin BlalockDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Stephen A HareDepartment of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom.
Clare M LloydInflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, United Kingdom.
Robert J SnelgroveInflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, United Kingdom.
Imperial College London · GBUniversity of Alabama at Birmingham · US

Funding

HL-A New Pathway for Neutrophil-induced Airway InflammationR01HL077783 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BLALOCK, J EDWIN · 2006 to 2016
$3.2M
Acquired LTA4H Dysfunction in COPDR01HL110950 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BLALOCK, J EDWIN · 2012 to 2015
$2.0M
Genetics of Smoke-Altered LTA4H in COPDR01HL126596 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BLALOCK, J EDWIN, CASTALDI, PETER · 2015 to 2018
$1.6M
PGP, A Possible Biomarker for COPD Exacerbations and or ProgressionR01HL114439 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BLALOCK, J EDWIN · 2012 to 2015
$1.5M
Medical Research Council G1000758Medical Research Council G1100332Medical Research Council MC_PC_13064NHLBI NIH HHS R01 HL077783NHLBI NIH HHS R01 HL110950NHLBI NIH HHS R01 HL114439NHLBI NIH HHS R01 HL126596Wellcome Trust 086718/Z/08/Z
6 · The paper itself

Abstract

The pro-inflammatory mediator leukotriene B

Indexed as

Amino Acid MotifsAnimalsAnti-Inflammatory Agentsbeta-AlanineBinding SitesBone Marrow CellsCrystallography, X-RayEnzyme InhibitorsEpoxide HydrolasesFemaleGene ExpressionHumansHydrolysisInflammationLeukotriene B4MiceAnti-Inflammatory Agentsbeta-AlanineEnzyme InhibitorsEpoxide Hydrolasesleukotriene A4 hydrolaseLeukotriene B4OligopeptidesProlineprolyl-glycyl-prolineRecombinant ProteinsSC 57461

Identifiers

PMID28303931
PMCPMC5355877
OpenAlexW2596264452

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.