ArticleScientific reports2017
Automated Protein Biomarker Analysis: on-line extraction of clinical samples by Molecularly Imprinted Polymers.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Recent progress, challenges, and future perspectives of electrochemical biosensing of aflatoxins.Mikrochimica acta · 2024Review
- Sensors Based on Molecularly Imprinted Polymers in the Field of Cancer Biomarker Detection: A Review.Nanomaterials (Basel, Switzerland) · 2024Review
- Elucidation of the Binding Orientation in α2,3- and α2,6-Linked Neu5Ac-Gal Epitopes toward a Hydrophilic Molecularly Imprinted Monolith.ACS omega · 2023Article
- Donor-acceptor Stenhouse adduct functionalised polymer microspheres.Polymer chemistry · 2023Article
- Review
- Recent molecularly imprinted polymers applications in bioanalysis.Chemicke zvesti · 2023Review
- Molecularly imprinted polymers for selective extraction/microextraction of cancer biomarkers: A review.Mikrochimica acta · 2022Review
- Molecularly Imprinted Polymers (MIPs) in Sensors for Environmental and Biomedical Applications: A Review.Molecules (Basel, Switzerland) · 2021Review
- Review
- Molecular Imprinted Polymers Coupled to Photonic Structures in Biosensors: The State of Art.Sensors (Basel, Switzerland) · 2020Review
- Magnetic Synthetic Receptors for Selective Clean-Up in Protein Biomarker Quantification.Journal of proteome research · 2020Article
- Immunocapture sample clean-up in determination of low abundant protein biomarkers - a feasibility study of peptide capture by anti-protein antibodies.RSC advances · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Robust biomarker quantification is essential for the accurate diagnosis of diseases and is of great value in cancer management. In this paper, an innovative diagnostic platform is presented which provides automated molecularly imprinted solid-phase extraction (MISPE) followed by liquid chromatography-mass spectrometry (LC-MS) for biomarker determination using ProGastrin Releasing Peptide (ProGRP), a highly sensitive biomarker for Small Cell Lung Cancer, as a model. Molecularly imprinted polymer microspheres were synthesized by precipitation polymerization and analytical optimization of the most promising material led to the development of an automated quantification method for ProGRP. The method enabled analysis of patient serum samples with elevated ProGRP levels. Particularly low sample volumes were permitted using the automated extraction within a method which was time-efficient, thereby demonstrating the potential of such a strategy in a clinical setting.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.